人工饲养条件下死亡实验恒河猴肠道病理改变特点分析  

Analysis of the Intestinal Pathological Changes in Dead Rhesus Monkeys Bred under Captive Conditions

作　　者：赵玺龙[1] 杨举伦[1] 宋蜀伶[1] 徐文漭[1] 潘鑫艳[1] 黎贵芸[1] 李锋 

机构地区：[1]解放军昆明总医院病理科实验动物病理检测中心,昆明650032 [2]云南省灵长类实验动物有限公司,昆明650216

出　　处：《中国比较医学杂志》2011年第12期21-25,96,共6页Chinese Journal of Comparative Medicine

基　　金：云南省科技基础条件平台建设项目(编号2005P T05)

摘　　要：目的观察人工饲养条件下实验恒河猴肠道病理改变,探讨实验猴肠道疾病分布规律和病理改变特点,丰富实验猴自发病变基本研究资料。方法对1998～2008年云南地区饲养的自然死亡的155只恒河猴(年龄2～20岁)的肠道进行病理检查,按年龄分为幼年组、成年组、老年组,并对观察结果进行统计学分析。结果 155例恒河猴中58例检出肠道病变,有慢性肠炎、急性肠炎、黏膜充血水肿、出血、糜烂、溃疡、穿孔、寄生虫共8种主要病变,出现率最高的为急性肠炎(20.00%)。实验猴不同年龄组肠道病变类型分布基本相同,肠道病变率随年龄增长而增高,不同年龄组间统计学分析差异无显著性。结论人工饲养条件下死亡实验猴肠道病变检出率较高,急性肠炎是实验猴的主要致死原因之一,实验猴肠道病理改变随年龄增长而病变加重。对实验猴饲养和研究时,应重视肠道病变因素,尤其是急性肠炎。死亡实验猴肠道病变研究对实验猴的质量控制和相关动物实验有重要指导价值。Objective To observe the intestinal pathological changes of dead rhesus monkeys bred under captive conditions, and to explore the rule of distribution of characteristic pathological changes. Methods One hundred and fifty- five naturally died monkeys in the age of 2 to 20 years, bred in institutes in Yunnan province, were autopsied from 1998 to 2008. The monkeys were divided into young, adult and old groups according to their age. The intestinal changes were investigated by routine histopathological examination and analysis by chi-square test. Results Of the 155 monkeys, 58 animals had intestinal lesions （37.42%）. The main lesions included chronic enteritis, acute enteritis, bleeding and erosion, ulcers, perforation, parasite infections and others. All kinds of intestinal lesions occured in the 3 age groups. Among these lesions the incidence rate of acute enteritis is the highest （20.00%） and increased with increasing ages. The chi-square test showed that the distribution of main intestinal lesions had no statistically significant difference among the 3 age groups. Conclusions The incidence rate of intestinal diseases in the bred rhesus macaques is high. The intestinal changes are not correlated with the ages of the captive rhesus macaques. Severe acute eneritis is the main cause of death of the captive monkeys. We should pay enough attention to the intestinal lesions, especially acute enteritis, when raise and study rhesus monkeys. The results of our test provide useful information in quality control of captive monkeys and relevant animal studies.

关 键 词：恒河猴 肠道 病理 尸检 人工饲养 猴 

分 类 号：R33[医药卫生—人体生理学]