匹多莫德口服液对急性加重期慢性阻塞性肺病患者细胞免疫的影响  

Influence of Pidotimod Oral Liquid on T Lymphocyte Immunological Function of Patients with COPD in Acute Exacerbation Stage

作　　者：马秀琴[1] 陈如华[1] 刘秀芳[1] 

机构地区：[1]宜兴市人民医院呼吸科,江苏宜兴214200

出　　处：《贵阳医学院学报》2011年第6期589-591,共3页Journal of Guiyang Medical College

摘　　要：目的:探讨匹多莫德口服液对慢性阻塞性肺病(COPD)急性发作期患者细胞免疫功能的影响。方法:将COPD急性发作期患者60例分为治疗组和对照组各30例,另选30例体检的健康老年人为正常对照组;对照组给予祛痰、平喘、抗炎、给氧常规治疗,治疗组除常规治疗外给予匹多莫德口服液,每天2次,每次0.4 g,疗程14 d,比较两组治疗后的临床疗效,同时检测治疗前后T细胞亚群的变化。结果:治疗组总有效率为96.7%,对照组为83.3%,治疗组优于对照组(P<0.05);两组COPD患者治疗前T细胞亚群CD+3、CD+4、CD+4/CD+8水平显著低于正常对照组,P<0.01;治疗组治疗后CD+3、CD+4、CD+4/CD+8均明显增加,与治疗前及治疗后对照组比较差异有显著性(P<0.05);对照组治疗前后CD+3、CD+4、CD+4/CD+8,差异无显著性(P>0.05)。结论:匹多莫德口服液可调理COPD急性发作期患者的T淋巴细胞免疫功能,明显改善患者的临床症状。Objective： To study the influences of pidotimod on T lymphocyte immunological function of patients with chronic obstructive pulmonary disease（COPD） in acute stage.Methods： Sixty patients with COPD in acute stage were randomly divided into treatment group（group T） and control group（group C）,and thirty healthy people were selected as healthy group（group H）.Group C accepted expectorant,anti-asthma,anti-inflammatory and oxygen therapies.Beside of conventional therapy,Group T was given pidotimod oral liquid 0.4 twice a day for 14 days.The clinical effects of the two groups after treatment were compared.Meanwhile,the changes of T cell subgroups were detected before and after treatment.Results： The total effective rate of group T was 96.7% and that of group C was 83.3%,which showed a notable difference between the two groups（P0.05）.The levels of CD＋3,CD＋4 and CD＋4/CD＋8 in two diseased groups were significantly lower than those in group H（P0.01）.After treatment,the levels of CD＋3,CD＋4 and CD＋4/CD＋8 in group T were obviously higher than those before treatment and those in group C（P0.05）.However,there was no significant difference of the above indexes in group C before and after treatment（P0.05）.Conclusions： Pidotimod could regulate T lymphocyte immunological function of patients with COPD in acute stage and obviously improve their clinical symptoms.

关 键 词：匹多莫德 肺疾病 慢性阻塞性 免疫 细胞 

分 类 号：R563[医药卫生—呼吸系统]