银杏叶片联合人际心理干预治疗冠心病伴抑郁症的临床研究  

Effects of Ginkgo biloba leaves extract tablets combined with interpersonal psychotherapy in coronary artery disease patients with depression

作　　者：袁佳[1] 张兰[1] 刘干[1] 钟金鹏[1] 邓艳梅[1] 殷跃辉[1] 苏立[1] 凌智瑜[1] 陈运清[1] 

机构地区：[1]重庆医科大学附属第二医院,重庆400010

出　　处：《中国新药与临床杂志》2011年第12期920-924,共5页Chinese Journal of New Drugs and Clinical Remedies

基　　金：国家自然科学基金(81070140);重庆市卫生局中医药科技项目(2008-2-45)

摘　　要：目的观察银杏叶片联合人际心理干预治疗冠心病合并抑郁症患者的疗效。方法该研究设计为单中心、随机对照研究,入选220例冠心病合并抑郁症患者,随机分为对照组(人际心理干预)和治疗组(银杏叶片48 mg,tid+人际心理干预),疗程6 mo。分别在治疗前和治疗后3、6 mo评定汉密尔顿抑郁量表24项(HAMD-24)和贝克抑郁量表(BDI-Ⅱ)评分,次要指标观察全因死亡率、因冠心病发作再次入院的情况和不良反应。结果治疗前2组HAMD-24评分和BDI-Ⅱ评分无显著差异(P>0.05);治疗3、6 mo末,2组的HAMD-24评分、BDI-Ⅱ评分均较治疗前显著改善(P<0.01),且治疗组比对照组改善更为显著(P<0.05)。治疗组3 mo时总有效率为37%,6 mo时总有效率为51%,分别高于同时点对照组(21%和29%,P<0.01)。2组在全因死亡率、不良反应和再次住院率上无显著差异(P>0.05)。结论应用银杏叶片联合人际心理干预治疗冠心病合并抑郁症,疗效优于单纯人际心理干预。AIM To explore the effect and safety of Shuganjieyu capsule in the treatment of generalized anxiety disorder（GAD）.METHODS A total of 70 patients who conformed to the GAD diagnosis standard of CCMD-3 were randomly divided into study group and control group with 35 patients in each group.The patients in the study group were given 4 Shuganjieyu capsules a day（2 after breakfast and 2 after supper）.The patients in the control group were given paroxetine 10 mg on d 1 and 20 mg on d 4,if necessary it can be increased to 30 - 40 mg a day（took once after breakfast） 7 days later.Patients with sleep disturbances were allowed to take Zolpidem 5-10 mg·d^（-1）（took once before sleeping）.The research course was 6 weeks.Evaluations were made by HAMA,HAMD-17 and TESS before the study and at the end of the week 1,2,4,6 after the administration.RESULTS There was no significance between the two group in the number of patients who took Zolpidem（P0.05）.The scores of HAM A and HAMD-17 of the two groups had significantly decreased since the end of week 1 till the end of the study（P0.01）,while the scores of HAMA and HAMD-17 between the two groups had no statistic significance before and after the treatment（P0.05）.The TESS scores of the study group were lower than that of the control group from the end of week 1 to 4（P0.05,P0.01）,and there was no statistic significance between them at the end of week 6（P0.05）.There were 18 patients in the study group and 20 patients in the control group cured.The remission rate and total effective rate was 51%and 77%in the study group,57%and 83%in the control group,respectively.There was no statistic significance in curative effect between the two groups（P0.05）.The main adverse reactions of the two groups were headache, dizziness,appetite decline and abnormal in liver function,all of which not serious.There were no significant differences in the adverse reaction rates of the two groups（P0.05）.CONCLUSION Shuganjieyu capsule not only has a rapid effect on the

关 键 词：银杏 心理疗法 冠状动脉硬化 抑郁症 随机对照试验 

分 类 号：R541.4[医药卫生—心血管疾病] R749.4[医药卫生—内科学]