阿苯达唑-聚乙二醇6000固体分散体壳聚糖微球的制备与药剂学性质研究  

Study on Preparation and Pharmaceutical Characteristics of Albendazole-PEG6000 Solid Dispersions-chitosan Microspheres

作　　者：王晓青[1] 刘扬[1] 陈袁兰[1] 朱爱军[1] 张光宇[1] 张学农[1] 任伟新[2] 迪理木拉提.巴吾东 顾俊鹏[2] 许晓东[2] 

机构地区：[1]苏州大学医学部药学院,江苏苏州215123 [2]新疆医科大学附属第一医院,乌鲁木齐830054

出　　处：《中国药房》2012年第5期424-427,共4页China Pharmacy

基　　金：国家自然科学基金资助项目(30960102)

摘　　要：目的:制备阿苯达唑-聚乙二醇6000(PEG)固体分散体壳聚糖微球并评价其性质。方法:以阿苯达唑-PEG固体分散体(ASD)为主体,壳聚糖为载体,采用乳化交联法制备ASD壳聚糖微球;采用电镜、红外光谱、X衍射分析法等对微球进行表征并考察其药剂学性质;动态透析法研究微球的体外释放特性。结果:所制得微球形态圆整,粒径分布均匀,平均粒径约(210±3.8)μm,载药量(6.42±0.32)%,包封率(57.86±0.74)%;红外光谱、X衍射分析法证明药物成功包载于微球中;微球在醋酸盐溶液(pH3.5)介质中的释放情况遵循Higuchi方程,可持续释放400h以上。结论:本法制备微球工艺稳定,所制微球具有显著的缓释效果。OBJECTIVE： To prepare Albendazole-PEG6000 solid dispersions （ASD）-chitosan microspheres, and to evaluate the property of it. METHODS： ASD chitosan microspheres were prepared by emulsion cross-linking technique using ASD as main component and chitosan as carrier. Superficial characteristics and pharmaceutical property of microspheres were investigated by elec- tronic microscope, IR-spectrum and X-ray diffraction. Dynamic dialysis system was adopted to study the drug release in vitro. RE- SULTS ： The microspheres were spherical in shape and even in particle size. The mean diameter was （210 ± 3.8） lam. The drug-loading amount and encapsulated efficiency of microspheres were （6.42 ± 0.32）% and （57.86 ± 0.74）%. IR-spectrum and X-ray diffraction indicated drug had been included in microspheres successfully. The release behavior of ABZ-PEG6000-CS-MS in acetate was in line with Higuchi model lasting for more than 400 h. CONCLUSION： The optimized technology presents good stability and excel- lent effect of sustained drug release.

关 键 词：阿苯达唑 聚乙二醇6000 固体分散体 壳聚糖 微球 制备 体外释放 

分 类 号：R943[医药卫生—药剂学] R978.6[医药卫生—药学]