甘草次酸/11-脱氧甘草次酸甲酯的合成  

Synthesis of Glycyrrhetinic Acid,11-deoxylglycyrrhetinic Acid Methyl Ester

作　　者：雍建平[1] 阿吉艾克拜尔.艾萨 

机构地区：[1]宁夏医科大学公卫学院,宁夏银川750004 [2]中国科学院新疆理化技术研究所,新疆乌鲁木齐830011

出　　处：《时珍国医国药》2011年第11期2618-2619,共2页Lishizhen Medicine and Materia Medica Research

基　　金：宁夏回族自治区自然科学基金(No.NZ10108);宁夏医科大学面上基金资助(No.XM201010);宁夏医科大学博士建设学科开放课题(No.KF2010-12)

摘　　要：以甘草次酸为原料,采用经典的克莱门森还原制备了11-脱氧甘草次酸,接着在不同的催化体系中(浓硫酸、浓盐酸、干盐酸气)研究了合成了甘草次酸甲酯的最佳条件,结果表明以干盐酸气催化可获得较高的产率。并在该条件下合成了11-脱氧甘草次酸甲酯。合成的化合物经过IR,1HNMR,13CNMR等进行了表征。11-deoxylglycyrrhetinic acid was synthesized by Clemmensen reduction using glycyrrhetinic acid as starting material.Then,their methyl esters were also synthesized catalyzed by different catalyst（dry HCl gas,concentrated H2SO4,concentrated HCl）.The results showed that it will obtain the good yield catalyzed by dry HCl gas among the above catalysts.The synthesized compounds were confirmed by IR,1HNMR,13CNMR and MS.

关 键 词：甘草次酸 11-脱氧甘草次酸 克莱门森还原 酯化反应 

分 类 号：R284.2[医药卫生—中药学]