野八角果实中的一个新苯丙素糖苷(英文)  

A new phenylpropanoid glycoside from the fruits of Illicium simonsii

作　　者：魏丹丹[1] 汪俊松[1] 张耀[1] 孔令义[1] WEI Dan-Dan;WANG Jun-Song;ZHANG Yao;KONG Ling-Yi(Department of Natural Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009,China)

机构地区：[1]中国药科大学天然药物化学教研室,南京210009

出　　处：《中国天然药物》2012年第1期20-23,共4页

基　　金：supported by the National Natural Science Foundation of China(No.30801514)~~

摘　　要：目的:研究野八角果实的化学成分及生物活性。方法:应用硅胶、反相及半制备HPLC色谱法对野八角果实的乙醇提取物进行分离纯化,并用MTT法对所分离化合物进行细胞毒活性测试。结果:分离鉴定了8个化合物,包括1个新的苯丙素糖苷2,4-dihydroxy-allylbenzene-2-O-β-D-glucopyranoside(1)和7个已知的倍半萜内酯oligandruminB(2),oligandruminD(3),anisatin(4),veranisatinD(5),pseudomajucin(6),1α-hydroxy-3-deoxy-pseudoanisatin(7),8α-hydroxy-10-deoxycyclomerri-llianolide(8)。结论:化合物1,2,3,58为首次从野八角果实中分离得到,所有化合物对非小细胞肺癌A549细胞株均无细胞毒活性。AIM： To study the constituents and bioactivity of lllicium simonsii. METHODS： The extracts of the fruits of lllicium simonsii were submitted to a combination of chromatographic materials, silica gel, ODS column chromatography and finally preparative HPLC to obtain eight compounds which were further evaluated for their cytotoxicity by MTT method. RESULTS： A new phenylpropanoid glycolside, 2, 4-dihydroxy-allylbenzene-2-O-fl-D-glucopyranoside （1）, together with seven characteristic sesquiterpene lactones, oligandrumin B （2）, oligandrumin D （3）, anisatin （4）, veranisatin D （5）, pseudomajucin （6）, la-hydroxy-3-deoxy-pseudoanisatin （7）, 8a-hydroxy-10-deoxycyclomerrillianolide （8） were isolated. CONCLUSION： Compound 1 is new. Compounds 1, 2, 3, 5--8 were isolated from this plant for the first time. None of the isolates showed inhibitory effects on the growth of non-small cell lung tumor cell line A549.

关 键 词：野八角 苯丙素糖苷 倍半萜内酯 细胞毒 

分 类 号：R284.1[医药卫生—中药学]