糖尿病肾病患者外周血单个核细胞前列腺素E1受体EP2mRNA表达及其对PGEl治疗的影响  

The mRNA Expression of PGE1 Receptor EP2 in Diabetic Nephropathy and Influence by PGE1 Treatment

作　　者：王玉新[1] 周丽娜[1] 张以勤[1] 叶婧[1] 武挺[1] 郭超群[1] 赵本华[1] 邹和群[1] 

机构地区：[1]厦门市第二医院肾内科,福建361021

出　　处：《国际泌尿系统杂志》2012年第1期31-34,共4页International Journal of Urology and Nephrology

摘　　要：目的探讨糖尿病肾病患者外周血单个核细胞前列腺素E1受体EP2mRNA的表达及其对PGEl治疗的影响。方法选择临床诊断为糖尿病肾病的67例患者作为研究对象，均给予前列腺素E1治疗，疗程2周，逆转录聚合酶链反应检测患者治疗前后外周血前列腺素El受体EP2mRNA表达水平，同时比较血压、尿蛋白及血肌酐水平变化。结果糖尿病肾病患者治疗后外周血单个核细胞前列腺素El受体EP2mRNA的表达水平较治疗前升高，且受体活性增高显著者疗效较好。结论在糖尿病肾病发病过程中，EP2受体可能参与了糖尿病肾病的发病过程。糖尿病肾病患者PGEt的治疗效果与受体EP2mRNA的表达相关。Objectives To investigate the mRAN expressions level of EP2 receptor in the peripheral blood mononuclear cells of patients with diabetic nephropathy （DN） and the influence by PGE1 treatment. Methods Sixty patients were treated with PGE1 for 2 weeks. The mRNA expressions of EP2 receptor were detected with RT - PCR. Results Meanwhile, we observed the changes of blood pressure, 24h urinary protein output, serum creati- nine level. The mRNA expression of EP2 receptor was elevated after treatment inpatients with diabetic nephropathy, The treatment effect of PGE1 in patients with higher EP2 mRNA expression was better. Conclusions It is sug- gested that EP2 receptor might be involved in the pathogenesis of diabetic nephropathy. The treatment effect of DN by PGE1 may be related with expressions of EP2 mRNA.

关 键 词：RNA 信使 

分 类 号：R587.2[医药卫生—内分泌]