星点设计-效应面法优化姜炭炮制工艺  

Optimization of Processing Technology of Ginger Carbon by Central Composite Design/Response Surface Methodology

作　　者：孟江[1] 许舒娅[1] 卢国勇[1] 廖华卫[1] 梁慧超[1] 林志豪[1] 

机构地区：[1]广东药学院中药学院,广州510006

出　　处：《中国实验方剂学杂志》2012年第2期8-11,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81102809);广东省高等学校大学生创新实验项目(1057310022)

摘　　要：目的:采用星点设计-效应面法优化姜炭的炮制工艺。方法:采用砂烫法以炮制温度、药材厚度、炮制时间为自变量,吸附力、鞣质含量、6-姜辣素含量和6-姜烯酚含量的总评"归一值"为评价指标,对自变量各水平进行多元线性回归和二项式拟合,用效应面法筛选最佳炮制工艺,并进行预测分析。结果:二项式拟合复合相关系数较高,总评"归一值"为0.870,最佳炮制工艺为炮制温度310℃,药材厚度0.55 cm,炮制时间15.5 min。最佳工艺验证结果与二项式拟合方程预测值偏差为-2.59%。结论:利用星点设计-效应面法优化姜炭提取工艺,方法简便,预测性良好。Objective：To optimize processing technology of ginger carbon by central composite design/response surface methodology.Method： Sand-scorch processing technology was adopted with processing temperature,medicine thickness,processing time as independent variables,and absorption power,the contents of tannins,6-gingerol and 6-shogaol as evaluation indexes,levels of independent were regressed by multiple linear and fitted by binomial,response surface methodology was used to select optimum processing technology,and predictive analyzed.Result： Complex correlation coefficient of binomial fitting was high,and overall ＇normalized value＇ was 0.870.Optimal processing technology were：processing temperature 310 ℃,medicine thickness 0.55 cm,processing time 15.5 min.Deviation between result of optimum craft verification test and binomial fitting equation forecast value was-2.59 %.Conclusion： Central composite design/response surface method could be used to optimize extraction technology of ginger carbon,and it was simple,had good prediction.

关 键 词：姜炭 炮制工艺 星点设计-效应面法 

分 类 号：R283.6[医药卫生—中药学]