无症状HIV感染者治疗前后血清新喋呤检测的临床意义  

Clinical Significance on Change of Serum Neopterin Level Before and After Treatment in Patients with Asymptomatic HIV Carriers

作　　者：王丹妮[1,2,3] 姜枫[2,3] 顾侦芳[2,3] 李政伟[2,3] 

机构地区：[1]南京中医药大学,南京210046 [2]河南中医学院第一附属医院艾滋病临床研究中心,郑州450000 [3]国家中医药管理局中医传染病学重点学科,郑州450000

出　　处：《中国实验方剂学杂志》2012年第2期225-227,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：科技部国际合作项目(2007DFB31610);国家自然科学基金项目(30901906;81102575);中国博士后科学基金项目(20080440743);国家"十一五"科技重大专项(2008ZX10005-002)

摘　　要：目的:探讨无症状人类免疫缺陷病毒(HIV)感染者治疗前后血清新喋呤(NPI)水平的变化及意义。方法:应用酶联免疫吸附法对32例无症状HIV感染者进行了血清NPI水平测定,并与22名健康体检者作比较。结果:32例无症状HIV感染者治疗前血清NPI浓度显著高于健康对照组(P<0.05)。无症状HIV感染者血清NPI经中药扶正排毒片1.85 g,3次/d相当于生药19.8 g,3次/d,温开水冲服,治疗6个月后与治疗前相比有明显下降,统计学有显著性差异(P<0.05),但仍高于健康对照组;治疗后与健康对照组相比有显著性差异(P<0.05)。结论:血清NPI水平升高代表的异常免疫激活是无症状HIV感染者的病理因素之一,扶正排毒片可以降低无症状HIV感染者血清NPI水平,是其疗效的可能机制之一。Objective： To explore the change of serum neopterin（NPI） levels before and after treatment in patients with asymptomatic human immunodefilienly virus（HIV） carriers.Method： ELISA method was used to determine serum NPI levels of 32 patients with asymptomatic HIV infection and 22 healthy subjects were entered control group.Result： Before treatment there was statistical significance in NPI compared with the healthy control group（P0.05）,after 6 months of treatment by Fuzheng Paidu tablet,there was statistical significance in the change of NPI（P0.05）,self-comparison before and after treatment was statistically significant（P0.05）.Conclusion： The abnormal immune activation induced by increased serum levels of NPI may be one of the pathological factors in patients asymptomatic HIV infection,Fuzheng Paidu table can reduce the level of serum NPI in asymptomatic HIV carriers,which may be one of the possible mechanisms.

关 键 词：无症状HIV感染者 新喋呤 扶正排毒片 

分 类 号：R287[医药卫生—中药学]