肺癌呼吸气体检测系统的气室设计  

Design of gas chamber of lung cancer respiratory gas detection system

作　　者：罗小刚[1] 汪德暖[1] 刘静静[1] 

机构地区：[1]重庆大学生物工程学院,重庆400030

出　　处：《传感器与微系统》2012年第1期90-93,96,共5页Transducer and Microsystem Technologies

基　　金：国家"863"计划资助项目(2006AA04Z349);国家自然科学基金资助项目(30770568);中央高校基本科研业务资金资助项目(CD-JXS10231117);重庆市自然科学基金资助项目(CSTC;2009BB5219);教育部高校博士点基金资助项目(20090191110030)

摘　　要：基于卟啉传感器阵列(PSA)的肺癌呼吸气体检测系统是通过采集处理PSA芯片表面图谱信息来对人体呼吸气体进行定性检测,达到早期肺癌诊断的目的。检测过程中,PSA芯片能否与气体分子快速、均匀结合将直接影响气体检测系统的准确度。以系统中PSA芯片与肺癌呼吸气体反应的气室为研究对象,借助CFD专用软件FLUENT对气室进行流场仿真结构优化,在气室理论模型的基础上,进行了气室实物制作,结果表明:通过采用抛物线形气室内腔、安装导流板、减小分流孔通径、适当加大分流孔倾斜角度等优化方案后,气室内呼吸气体呈层流流动状态,流场更加均匀、密集,能达到检测系统中PSA芯片与呼吸气体分子快速、均匀结合的要求。Lung cancer respiratory gas detection system based on Porphyrin sensor arrays （PSAs）is used to detect human respiratory gases qualitatively through the acquisition and processing the information of PSA images, to achieve the purpose of early lung cancer diagnosis. In the detection process, whether PSA chips can bind gas molecules rapidly and uniformly, directly affects the accuracy of detection system. The chamber in which PSA chips reacts with lung cancer respiratory gases as the research object, is produced physically on the basis of the gas theoretical model with FLUENT which is a kind of CFD special software, simulating the gas chamber flow filed and optimizing its structure. The results show that the gas chamber using the optimization options of parabolic chamber cavity, installation of guide plates, reducing the diameter of diversion holes and increasing the tilt angle of diversion holes appropriately,in which the respiratory gases show a laminar flow state and the flow field is more uniform and dense, can achieve the requirements of PSA chips binding with gas molecules rapidly and uniformly.

关 键 词：卟啉传感器阵列 气体检测 气室 肺癌 

分 类 号：TP212.2[自动化与计算机技术—检测技术与自动化装置]