MR扩散加权成像的肝泡状棘球蚴边缘带影像特征与组织病理学对照分析  

Comparison between the MR diffusion weighted imaging and pathology of hepatic alveolar echinococcosis

作　　者：任波[1] 王静[1] 刘文亚[1] 温浩[2] 张巍[3] 肖虎[1] 

机构地区：[1]新疆医科大学第一附属医院影像中心,乌鲁木齐830054 [2]新疆医科大学第一附属医院普外科,乌鲁木齐830054 [3]新疆医科大学第一附属医院病理科,乌鲁木齐830054

出　　处：《中华放射学杂志》2012年第1期57-60,共4页Chinese Journal of Radiology

基　　金：基金项目：国家自然科学基金资助项目（30960100）

摘　　要：目的探讨DWI及ADC值在评价肝泡状棘球蚴病（HAE）病变性质中的价值。方法26例HAE患者行肝脏常规MRI和DWI，b值分别为500、800s／mm2，获得病灶中心实性区（ADC中心）、边缘带（ADC边缘）、外周区（ADC外周）ADC值，采用单因素方差分析比较各区域ADC值。观察病灶标本的特点，取病灶边缘区域行HE染色和免疫组织化学测定微血管密度（MVD），并采用Pearson法分析边缘带ADC值与MVD的相关性。结果选取26例HAE患者中独立病灶32个进行ADC值测量，b值分别为500、800s／mm2时，ADC中心、ADC边缘和ADC外周值分别为（1．3±0．3）×10^-3、（1．1±0．4）×10^-3、（1．8±0．5）×10^-3mm2／s，（1．2±0．4）×10^-3、（1．1±0．3）×10^-3、（1．9±0．4）×10^-3mm2／s，不同b值下各区域ADC值差异均有统计学意义（P值均〈0．01），两两比较结果差异亦有统计学意义（P值均〈0．05）。26例32个病灶边缘区域MVD值为（12．9±3．7）个／视野，与不同b值下ADC值均无相关性（r值分别为-0．042和-0．077，P值均〉0．05）。结论DWI可以反映HAE病灶不同区域特征，而病灶边缘区域的ADC值与该区域MVD无相关性。Objective To explore the value of DWI and ADC in evaluation the pathologic characteristics of hepatic alveolar echinococcosis （HAE） . Methods Twenty six patients with HAE underwent routine MRI and DWI （ b = 500, 800 s/mm2 ） scan, ADC values of different part including the center, peripheral area and surrounding zone of the lesion were measured, respectively. One-way ANOVA was used for comparing the ADC values of two groups. HE staining specimens and MVD of peripheral area of the lesion were analyzed by different pathological staining methods. The correlation between MVD and ADC values of the peripheral area was analyzed by using the Pearson rank correlation analysis. Results Totally 32 lesions were detected in 26 HAE patients. The ADC values of the center, the peripheral zone and the surrounding area of the lesions were （1.3 ±0.3） ×10^-3, （1.1 ±0.4） ×10^-3 and （1.8 ±0.5） ×10^-3 mm2/s when b = 500 s/mm2 , but when b = 800 s/ram2 , the ADC values were （ 1.2 ± 0. 4） ×10^-3, （ 1.1 ± 0. 3 ） ×10^-3 and （ 1.9 ± 0.4 ） ×10^-3 mm2/s, respectively. There were significant difference of the ADC values between two groups（P 〈0. 01 ）. The significant differences of the ADC values were also found in different area of the lesion （ P 〈 0. 05 ）. There were no correlation was found between ADC value and MVD [（12.9 ± 3.7）/HP] in the peripheral area of HAE（r = -0.042 and -0.077,P 〉0.05）. Conclusions DWI reflected the heteromorphism of peripheral zone and help to identify the infiltration area and biological boundary. No relationship was found between the ADC values of peripheral zone of lesion and MVD.

关 键 词：棘球蚴病 肝 磁共振成像 对照研究 

分 类 号：R445.2[医药卫生—影像医学与核医学]