妊娠相关蛋白-A对冠心病易损斑块的预测价值  

Pregnancy associated plasma protein-A predicts vulnerable plaque in coronary artery disease

作　　者：靳奇峰[1] 王彦富[2] 陈园园[1] 石胜伟[2] 孙景芝[2] 张慧玲[2] 刘燕[3] 吴德光[1] 李清贤[2] 

机构地区：[1]天津医科大学研究生院,天津300192 [2]山东省心脏疾病诊疗重点实验室 济宁医学院附属医院心内一科 [3]山东大学医学院

出　　处：《临床心血管病杂志》2012年第1期28-30,共3页Journal of Clinical Cardiology

基　　金：山东省自然科学基金项目(No:ZR2010HL032)

摘　　要：目的:探讨妊娠相关蛋白A(PAPP-A)与冠心病及斑块易损性之间的关系。方法:选择急性冠状动脉综合征(ACS组)患者20例,稳定性心绞痛(SAP组)患者19例,采用ELISA测定患者血清中PAPP-A水平,同时应用光学相干断层成像技术测定患者斑块纤维帽厚度。结果:ACS组PAPP-A高于SAP组[(48.71±18.90)ng/L∶(18.93±11.11)ng/L,P<0.01];ACS组斑块纤维帽厚度低于SAP组[(45.44±18.25)μm∶(90.74±24.54)μm,P<0.01]。ACS组中PAPP-A与斑块纤维帽厚度呈负相关,r=-0.778,P<0.01。逐步(Stepwise)多重线性回归分析认定PAPP-A是预测斑块易损性的一种独立危险因素。结论:PAPP-A是一种独立的、能够有效预测冠心病风险以及斑块易损性的标记物。Objective：To analysis the relationship between pregnancy associated plasma protein-A（PAPP-A） and vulnerable plaque in coronary artery disease.Method：There were 20 cases in ACS group and 19 in SAP group.The levels of PAPP-A were determined by enzyme linked immunosoebent assay（ELISA）,and OCT was used to measure the fibrous cap thickness of coronary artery atherosclerotic plaques.Result：The levels of PAPP-A in ACS group were significantly higher than those in SAP group（[48.71±18.90]ng/L∶[18.93±11.11]ng/L,P0.01）.Fibrous cap thickness of plaques in ACS group were thinker than those in SAP group（[45.44±18.25]μm∶[90.74±24.54]μm,P0.01）. The levels of PAPP-A（r=-0.778,P0.01） were correlated negatively with fibrous cap thickness in ACS patients.Gradually（Stepwise） multiple linear regression analysis identified that PAPP-A predicted vulnerability as an independent risk factor.Conclusion：PAPP-A,as an independent and effective marker,can predict the risk of coronary disease and vulnerable plaque.

关 键 词：冠心病 妊娠相关蛋白A 光学相干断层成像 易损斑块 纤维帽厚度 

分 类 号：R541.4[医药卫生—心血管疾病]