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作 者:黄峥嵘[1] 周洁琼[1] 李卫华[1] 谢强[1] 吴荣[1] 唐蓉[1] 马欲晓[1] 万晓群[1] 郑武扬[1] 张紫冠[1]
出 处:《中华老年医学杂志》2012年第1期21-24,共4页Chinese Journal of Geriatrics
基 金:国家自然科学基金(81170090);福建省自然科学杰出青年基金(20090015);厦门市杰出青年科技人才创新计划(350220116009);厦门市科技局科研基金(3502220094006)
摘 要:目的探讨心室晚电位(LP)预测Brugada综合征患者发生心律失常事件的价值。方法43例Brugada综合征患者分为有症状组(24例)和无症状组(19例)。采用信号平均心电图(sAEcG)检测所有患者的心室晚电位;动态随访(33.8±9.0)个月,观察研究人群中心律失常事件的发生情况。结果有症状组中有22例(91.7%)患者晚电位阳性,无症状组中有7例(36.8%)晚电位为阳性。LP阳性的Brugada综合征患者心律失常事件发生率为72.4%,LP阴性的Brugada综合征患者心律失常事件发生率为14.3%,LP预测心律失常事件发生的相对危险度(RR)为5.1,95%可信区间(CI)为[1.4,18.63(P=0.002)。结论心室晚电位可以作为Brugada综合征患者发生心律失常事件的有效预测因子之一。Objective To explore the predictive value of ventricle late potential (LP) for arrhythmic events in the patients with Brugada syndrome. Methods Totally 43 patients with Brugada syndrome were divided into symptom group (n 24) and asymptom group (n=19). Signal averaged electrocardiography(SAECG) was performed to analyze characteristics of LP in all subjects. The occurrence of arrhythmic events was observed in all patients during the dynamic follow up for (33.8±9.0) months. Results There were 22 cases (91.7%) and 7 cases (36.8%) with LP positive in patients with symptom and asymptom, respectively. The incidences of arrhythmic events were 72.4% in Brugada syndrome patients with positive LP and 14.3% in patients with negative LP, respectively. The relative risk (RR, 95% CI) for LP prediction of the arrhythmic events was (5.1, (1.4-18.6)3(P=0. 002). Conclusions LP may be one of effective factors predicting arrhythmic events in the patients with Brugada syndrome.
关 键 词:BRUGADA综合征 前瞻性研究 心电描技术 心律失常
分 类 号:R541.7[医药卫生—心血管疾病]
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