3种方案治疗骨质疏松症2年疗效分析  

Comparison of three Therapy Results in a 2-year Research on Osteoporosis

作　　者：马俊岭[1] 侯钦午[1] 史历[1] 阳晓东[1] 郭海英[1] 黄淑贤[1] 贺明华[1] 

机构地区：[1]上海市浦东新区北蔡社区卫生服务中心,上海201204

出　　处：《中国初级卫生保健》2012年第1期108-110,共3页Chinese Primary Health Care

基　　金：浦东新区卫生系统医学领先人才培养项目(PWRd2008-3);上海市浦东新区科技发展基金创新资金项目(PKJ2008-Y24)

摘　　要：目的观察3种方案治疗老年骨质疏松症(osteoporosis,OP)2年的疗效。方法选取2008年10月—2009年6月经骨质疏松筛查T值<-2的120例受试者,随机分为3个治疗组。中成药组(A组):补骨脂颗粒(20g/次,2次/日,口服)单药连续使用3个月后,改用仙灵骨葆(3粒/次,2次/日,口服)单药连续使用21个月。西药组(B组):依降钙素(10U/次,2次/周,肌注)单药连续使用3个月后,福善美(70mg/次,1次/周,口服)+阿法迪三(0.5μg/次,1次/日,口服)联用连续使用21个月。中西药联合组:A组+B组方案联合治疗。测定治疗始、治疗后12个月、24个月的腰椎、左髋部的骨密度值(Bone mineraldensity,BMD)。结果西药组和中西药组BMD均呈上升趋势,中药组总体以下降趋势为主,治疗12个月后改变下降趋势,呈上升趋势。3个组BMD的变化值比较,在L1、L2-4和髋全部差异有统计学意义(P<0.05),其余部位差异均无统计学意义(P>0.05)。两两比较中药组与西药组、中药组与中西药组差异有统计学意义(P<0.05),西药组与中西药组差异无统计学意义。结论 3种方案治疗骨质疏松症均有疗效,中药作用缓慢,西药作用较快。OBJECTIVE Investigate the effects of three medications on senile osteoporosis in a 2-year study. METHODS A total of 120 osteoporosis patients, selected from the candidates which were T〈-2 during Oct.2008 to Jun.2009, were assigned randomly into three groups. Group A （Traditional Chinese Medicine）： Patients received Bugu capsule （20 g Bid p.o.） for the first 3 months, then XianlingGubao （3# Bid p.o.） only for the next 21 months. Group B （Western Medicine）： Elcatonin （10u？ Biw .im.）for the first 3 months, then Fosamax（70mg QW p.o.） and alfaealcidol （0.5 μg qdp.o.） for the next 21 months. Group C （integrated Chinese and Western medicine）： patients were treated with both A and B protocols. Test the BMD value of lumbar spine and left hip at the beginning, the 12th month and the 24th month. RESULTS BMD value of Group B and Group C both went upward during the treatment. BMD value of Group A went down overall, but altered the trend since the 12th month. The BMD value changes of the 3 groups at L1, L2-4 and all the hip were significantly different（P〈0.05）, but the other parts＇ were not（P〉0.05）. In comparison, the differences between Group A and B, Group A and C are both statistically significant, while there is no significant difference between Group B and C. CONCLUSION All of the three medical treatments are effective in fighting against senile osteoporosis. The therapeutic efficiency of the Western Medicine was higher as compared to that of the traditional Chinese Medicine.

关 键 词：骨密度 骨质疏松症 依降钙素 阿仑膦酸钠 仙灵骨葆 阿法骨化醇 

分 类 号：R592[医药卫生—老年医学]