喹诺酮键联卟啉合成及与牛血清白蛋白的相互作用  

Synthesis of Quinolone-bonded Porphyrins and Their Interaction with Bovine Serum Albumin

作　　者：江国防[1] 刘永波[1] 吴谦[1] 曾春姣[1] 王开吉[1] 郭灿城[1] 

机构地区：[1]湖南大学化学化工学院,湖南长沙410082

出　　处：《湖南大学学报（自然科学版）》2012年第1期67-70,共4页Journal of Hunan University:Natural Sciences

基　　金：国家自然科学基金资助项目(20502005;J0830415);湖南省科技计划项目(2008GK2023;2010GK3157);湖南省自然科学基金资助项目(09JJ6024)

摘　　要：基于卟啉化合物的光敏性和对肿瘤细胞有特殊的亲和力以及喹诺酮类化合物的抗癌活性,设计合成了10个喹诺酮键联卟啉化合物,其结构由1 H NMR,IR,UV-Vis和MS表征.同时,利用荧光光谱考察了上述喹诺酮键联卟啉与牛血清白蛋白(BSA)的相互作用,结果表明它们对BSA荧光有较强的静态猝灭作用.Ten quinolone-bonded porphyrins were designed and synthesized on the basis of both porphyrin＇s photosensitivity and special affinity for tumor cells and quinolones＇ antitumor and anticancer activities. The molecular structures of all synthesized compounds were characterized with ^1H NMR, IR, UV- Vis and MS. The interaction between quinolone-bonded porphyrins and bovine serum albumin （BSA） was investigated with fluorescence spectrum. The results have shown that these new quinolone-bonded porphyrins have a powerful ability of quenching the fluorescence of BSA via static quenching.

关 键 词：卟啉 喹诺酮 牛血清白蛋白 合成 荧光光谱 

分 类 号：O621.33[理学—有机化学] O657[理学—化学]