铜绿假单胞菌临床分离株感染及耐药性的研究  

Analysis of infection and drug-resistance among some clinical isolated pseudomonsa aeruginosa

作　　者：王玉巧[1] 王丽娟[1] 张跃斌[1] 马玉龙[1] 刘辉[1] 

机构地区：[1]宁夏自治区人民医院,宁夏银川750021

出　　处：《宁夏医学杂志》2012年第1期17-19,共3页Ningxia Medical Journal

基　　金：宁夏自然科学基金项目(NZ09148)

摘　　要：目的研究临床铜绿假单胞菌感染及耐药情况。方法收集2009～2010年临床分离的铜绿假单胞菌,经全自动微生物分析系统鉴定,采用琼脂对倍稀释法进行药敏测定,分析连续2年铜绿假单胞菌的感染及耐药性变化情况。结果 2009及2010年分别收集铜绿假单胞菌为113株和132株,痰液为铜绿假单胞菌的主要标本来源,感染主要发生在ICU、呼吸内科、神经外科;铜绿假单胞菌对亚胺培南的耐药率最低,其次为头孢他啶及头孢哌酮/舒巴坦;对左氧氟沙星和阿米卡星的耐药率有所上升,对其他抗生素敏感率变化不大。结论 2年监测结果显示,铜绿假单胞菌的耐药类型及分布基本相似,亚胺培南对于铜绿假单胞菌感染仍是最有效的药物。Objective To investigate and compare infection distribution and drug-resistance of pseudomonsa aeruginosa isolates collected from Ningxia People＇s hospital.Methods Pseudomonsa aeruginosa strains were separated from January 2009 to December 2010.Fully-automatic microbial analysis system was used to identify these strains.Susceptibility test of these strains were detected with Bengal gelatine two-fold dilution method.Results 113 and 132 strains pseudomonsa aeruginosa were collected from our hospital;There exceed 40 percent of strains were isolated from sputum;Infection with pseudomonsa aeruginosa were mainly at intensive care unit,respiratory medicine and neurosurgery;Most of pseudomonsa aeruginosa strains were susceptible to imipenem,followed with cepoperazon /sulbactam and potendol,the rate of levofloxacin and amikacin resistance in 2010 were higher than in 2009.Conclusion Drug-resistance of pseudomonsa aeruginosa strains threatens the treatment of infections.It is very important to rationally use antimicrobial agents.

关 键 词：耐药性 铜绿假单胞菌 感染 

分 类 号：R446.5[医药卫生—诊断学]