雄黄对大鼠脑组织能量代谢的影响  

Effect of realgar on energy metabolism in brain tissues of rat

作　　者：霍韬光[1] 杨卉蕾[1] 畅蓓[1] 李维凯[1] 张颖花[1] 姜泓[1] 

机构地区：[1]中国医科大学公共卫生学院,辽宁沈阳110001

出　　处：《化学研究》2012年第1期53-55,共3页Chemical Research

基　　金：国家自然科学基金资助项目(81073144);辽宁省自然科学基金资助项目(20092133);辽宁省教育厅高等学校科研资助项目(L2010708)

摘　　要：将32只Wistar大鼠随机分为对照组(口服0.5%羧甲基纤维素钠溶液)以及低剂量(0.3g/kg)、中剂量(0.9g/kg)和高剂量(2.7g/kg)雄黄混悬液处理组,通过6周连续灌胃给服雄黄混悬液,采用高效液相色谱法测定大鼠脑组织中三磷酸腺甙(ATP)的含量,研究了雄黄对大鼠脑组织能量代谢的影响.结果表明,与对照组比较,雄黄染毒组大鼠脑组织中ATP含量均呈下降趋势(P<0.05),不同剂量组间未表现明显差异(P>0.05).这表明雄黄对大鼠脑组织能量代谢具有一定的抑制作用.32 Wistar rats were randomly categorized into control group as well as low dosage, moderate dosage, and high dosage realgar-treated groups. The control group was orally fed with the solution of 0.5 % sodium carboxymethylcellulose for 6 weeks, while the realgar treated groups were treated with realgar suspension by gastric perfusion at a dosage of 0.3 g/kg, 0.9 g/kg, and 2. 7 g/kg, respectively, for the same duration. The content of adenosine triphosphate （ATP） in the brain tissues of the tested rats was determined by means of high performance liquid chromatography, and the effect of realgar on energy metabolism in the brain tissues of the rats was investigated. Results show that the content of ATP in the brain tissues of the realgar-treated groups tends to decrease as compared with the control group （P〈0.05）, and no significant differences are observed among the three realgar-treated groups （P〉0.05）. This indicates that realgar can inhibit the energy metabolism in rat brain.

关 键 词：雄黄 大鼠 脑组织 能量代谢 

分 类 号：O613.63[理学—无机化学]