纳微多药给药系统的设计与研究  

Nano/Micro Scale Systems for Multiply Drugs Delivery

作　　者：王伯初[1] 曹阳[1] 张广求[2] 王亚洲[1] 张琳[1] 郝石磊[1] 娄德帅[1] 

机构地区：[1]重庆大学生物工程学院,重庆400030 [2]云南民族大学化学与生物技术学院,云南昆明650031

出　　处：《云南民族大学学报（自然科学版）》2012年第1期1-5,共5页Journal of Yunnan Minzu University:Natural Sciences Edition

基　　金：中央高校基本科研业务费专项资金(CDJZR10230006);重庆大学研究生优博创新团队(201105A1001)

摘　　要：化疗是肿瘤等重大疾病的主要治疗手段,但由于肿瘤复杂的发病机制以及耐药性的产生极大地限制了传统单一化疗药物的临床应用.基于联合给药策略的多药给药系统,具有同时装载多种药物和药物释放行为的可控性等特点.主要就纳微多药给药系统的背景以及设计研究现状展开综述,希望为后来的研究给以启发.As one of the main cancer therapeutic methods, chemotherapy plays a vital role in clinical practice. Howev- er, the traditional chemotherapy drugs and the dosage regimens have lots of limits, such as narrow therapeutic window, lower stability, toxicity, and lack of targeting, due to the metabolism barriers and the physical and chemical properties of these drugs. Combination of multi - drug for chemotherapy has been a consideration strategy in cancer therapy, and the controlled release of multiple drugs could minimize the toxicity, enhance synergy and maximize the efficacy of treatment This article focuses on the rational design and the current status of multi -drug delivery systems.

关 键 词：给药系统 多药 纳米/微米 联合给药 

分 类 号：R319[医药卫生—基础医学]