6组不同用药方案治疗社区2型糖尿病的成本-效果分析  

Cost-effectiveness analysis of 6 different schemes for treating community type 2 diabetes

作　　者：谢燕娇[1] 陈道雄[1] 刘嫱[2] 

机构地区：[1]海南省人民医院国兴门诊部,海口571101 [2]海南医学院药学院药理教研室,海口571101

出　　处：《检验医学与临床》2012年第2期153-154,共2页Laboratory Medicine and Clinic

摘　　要：目的评价不同用药方案治疗2型糖尿病的经济成本、不良反应及药物疗效。方法针对筛选出的230例2型糖尿病患者,按不同的用药方案随机分为6组,对其在治疗前和治疗12周结束后的经济效果、不良反应及药物疗效进行分析。6种不同用药方案为:盐酸二甲双胍片(A组),瑞格列奈片(B组),胰岛素注射液(C组),盐酸二甲双胍片联合瑞格列奈片(D组),胰岛素注射液联合二甲双胍片(E组),二甲双胍片联合阿卡波糖片(F组)。结果在各组用药方案中,D、E组在治疗后的空腹血糖(FPG)、餐后2h血糖(2hPBG)、糖化血红蛋白(HbA1c)控制较理想,治疗成本相对低。结论各组治疗2型糖尿病的用药方案疗效均较好,且D方案更符合药物经济学原则。Objective To evaluate the economic effect,adverse reactions and curative effect of 6 kinds of different schemes on treating type 2 diabetes.Methods 230 cases of type 2 diabetes were randomly divided into 6 groups according to 6 kinds of different treatment schemes.The economic effectiveness,adverse reactions and medication effects were analyzed before treatment and after12-weeks treatment.Six kinds of different treatment schemes were as follows：metformin（group A）,repaglinide（group B）,insulin injection（group C）,metformin＋ repaglinide（group D）,insulin injection ＋ metformin（group E） and metformin ＋ acarbose（group F）.Results Among various groups,fasting plasma glucose（FPG）,2 h postmeal blood glucose（2 h PBG） and（glycosylated hemoglobin） HbA1c in the group D and E were ideally controlled with relatively low costs.Conclusion The treatment schemes in various groups have better efficacy in treating type 2 diabetes.The scheme in the group D is better in line with the principles of pharmacoeconomics.

关 键 词：2型糖尿病 二甲双胍 胰岛素 瑞格列奈 成本-效果分析 

分 类 号：R587.1[医药卫生—内分泌]