血清糖类抗原及癌胚抗原联合检测在肺癌诊断中的意义  

Significance of combined detection of carbohydrate antigen and carcinoembryonic antigen in diagnosing lung cancer

作　　者：鲁礴[1] 杨玉梅[1] 

机构地区：[1]湖北省襄阳市东风汽车公司襄樊医院,441004

出　　处：《检验医学与临床》2012年第2期172-173,176,共3页Laboratory Medicine and Clinic

摘　　要：目的评价联合检测血清糖类抗原CA199、CA125、CA153及癌胚抗原(CEA)4项指标对肺癌的诊断价值。方法选取53例肺癌患者作为肺癌组,48例同期住院的良性肺疾病患者作为良性肺疾病组,50例同期体检合格的健康成人作为健康对照组,采用化学发光免疫分析法检测3组入选对象的CA199、CA125、CA153、CEA血清水平并进行对比。结果肺癌患者血清CA199、CA125、CA153、CEA值均明显高于健康对照组及良性肺疾病组,差异均有统计学意义(P<0.05);CA199、CA125、CA153、CEA 4项指标联合检测的敏感性(75.84%)和较单项指标检测敏感性(CA199为23.12%,CA125为38.45%,CA153为21.33%,CEA为35.11%)均有提高,差异均有统计学意义(P<0.05)。结论联合检测血清CA199、CA125、CA153及CEA能提高对肺癌的阳性检出率,临床诊断价值更大。Objective To investigate the diagnostic value of combined detection of four tumor markers carbohydrate antigen CA199,CA125,CA153 and carcinoembryonic antigen（CEA） in lung cancer.Methods Serum levels of CA199,CA125,CA153 and CEA in 53 cases of lung cancer,48 cases of benign lung lesions and 50 normal controls were detected by chemiluminescence immunoassay.Results Serum CA199,CA125,CA153 and CEA levels in lung cancer patients were significantly higher than those in normal controls and benign lung lesions patients with statisticaldifference（P0.05）.The sensitivity for diagnosing lung cancer in the combination detection of serum CA199,CA125,CA153 and CEA were 75.84%.The sensitivity in single detection were 23.12% for CA199,38.45% for CA125,21.33% for CA153,and 35.11% for CEA.The sensitivity in the combination detection were increased compared with detection of single index,showing statistical difference（P0.05）.Conclusion Combined determination of serum CA199,CA125,CA153 and CEA can improve the sensitivity and specificity in the diagnosis and differential diagnosis of lung cancer.

关 键 词：糖类抗原 肺癌 癌胚抗原 

分 类 号：R446.62[医药卫生—诊断学]