游离PSA、总PSA在前列腺增生与前列腺癌诊断中的应用价值  

Application value of free PSA and total PSA in diagnosis of benign prostatic hyperplasia and prostate cancer

作　　者：张敏[1] 王尚武[1] 

机构地区：[1]湖南省桃江县人民医院检验科,413400

出　　处：《检验医学与临床》2012年第2期177-178,共2页Laboratory Medicine and Clinic

摘　　要：目的探讨血清总前列腺特异性抗原(t-PSA)、游离前列腺特异性抗原(f-PSA)和游离与总前列腺特异性抗原比值(f/t比值)对前列腺癌(PCA)和良性前列腺增生(BPH)的诊断和鉴别诊断价值。方法采用化学发光全自动免疫分析仪分别检测经临床确诊的24例PCA和82例BPH患者血清中的f-PSA与t-PSA,计算f/t比值,并进行统计学分析。结果两组间血清t-PSA、f-PSA和f/t比值变量比较,BPH组与PCA组的t-PSA含量差异无统计学意义(P>0.05),而f-PSA、f/t比值差异具有统计学意义(P<0.05)。结论 t-PSA、f-PSA与f/t比值能较好地诊断和鉴别诊断PCA与BPH,但当t-PSA值在4～10ng/mL时t-PSA不能作为鉴别诊断依据,必须结合f-PSA和f/t比值才能更好地鉴别诊断PCA与BPH。Objective To discuss the value of total prostate specific antigen（t-PSA）,free prostate specific antigen（f-PSA） and f/t PSA ratio in the diagnosis and differentiation diagnosis of prostate cancer（PCA） and benign prostatic hyperplasia（BPH）.Methods The automated chemiluminescence system was adopted to detect f-PSA,t-PSA in 24 patients with PCA and 82 patients with BPH diagnosed clinically,and then the f/t ratio was calculated for statistic analysis.Results Comparing t-PSA,f-PSA and the f/t PSA ratio between two groups,there was no statistical difference in t-PSA between the benign prostatic hyperplasia group and the prostate cancer group（P0.05）,while there were statistical differences in f-PSA and f/t-PSA ratio between two groups（P0.05）.Conclusion Generally speaking,t-PSA,f-PSA and the f/t-PSA ratio can be used to preferably diagnose and differentiate PCA and BPH;but when the t-PSA value is between 4-10 ng/mL,it can not be treated as the reference of differentiation and diagnosis,which should be integrated with f-PSA and the f/t PSA ratio for the better diagnosis and differentiation of PCA and BPH.

关 键 词：前列腺增生 前列腺癌 化学发光测定法 前列腺特异性抗原 

分 类 号：R697.32[医药卫生—泌尿科学]