新型磁共振成像对比剂的制备与光谱研究  

Synthesis and Spectral Research of New Magnetic Resonance Imaging Contrast Agents

作　　者：龚玉珍[1] 殷彬励[1] 张小燕[1] 张岐[1] 李华明[1] 

机构地区：[1]江苏大学化学化工学院

出　　处：《光谱实验室》2012年第1期35-38,共4页Chinese Journal of Spectroscopy Laboratory

基　　金：江苏省高校自然科学研究项目(10KJB430006);江苏大学高级专业人才科研启动基金(10GDG060);江苏大学学生科研项目(09A052);江苏省科技支撑计划(SBE201077304)

摘　　要：以六氯环三膦腈和4,4'-二羟基二苯砜为原料合成聚膦腈纳米管(PZSNT),然后与顺磁性金属离子(Mn^(2+)、Fe^(2+)、Co^(2+)、Ni^(2+))配位制备出纳米管磁共振成像对比剂。利用傅里叶变换红外光谱仪对PZSNT及其产物进行结构表征;用原子吸收光谱法(AAS)检测PZSNT对金属离子的吸附洗脱性能,选用5%醋酸溶液对其进行洗脱,检测结果表明PZSNT对Mn^(2+)吸附效果最好;同时还用紫外可见吸收光谱技术研究了PZSNT与金属离子的相互作用。New magnetic resonance imaging contrast agents were synthesized by combining polyphospanzenes nanotubes（PZSNT） with paramagnetic metallic ions.The PZSNT were prepared using hexachlorocyclotriphosphazene and 4,4＇-sulfonyldiphenol as raw materials.The structures of PZSNT and the new magnetic resonance imaging contrast agents were characterized by FTIR.The adsorption and elution of PZSNT on metal ions using 5%acetic acid solution as eluents were investigated by AAS.The AAS results demonstrated that the interaction between PZSNT and manganese ions was strongest.The interaction of PZSNT with metal ions was also studied by UV-Visible absorption spectrum.

关 键 词：聚膦腈纳米管 顺磁性金属离子 吸附 

分 类 号：O657.61[理学—分析化学]