4(5)-氰基咪唑的合成与表征  

Synthesis and Characterization of 1H-Imidazole-4-Carbonitrile

作　　者：梁倩倩[1] 林原斌[1] 

机构地区：[1]湘潭大学化学学院环境友好化学与应用省部共建教育部重点实验室

出　　处：《光谱实验室》2012年第1期58-60,共3页Chinese Journal of Spectroscopy Laboratory

基　　金：国家自然科学基金资助项目(No.30470388)

摘　　要：以D-果糖为初始原料,经环合、氧化,再加入盐酸羟胺作为氰基化试剂一步法制得4(5)-氰基咪唑。利用~1H NMR、^(13)C NMR等手段对各步所得产物的结构进行了表征,结果表明产物为4(5)-氰基咪唑。以D-果糖计,3步反应的总收率为33.5%。~1H-Imidazole-4-carbonitrile were synthesized with D-fructose as starting materials by cyclization,oxidation and cyanation in a one-spet process by adding hydroxylamine hydrochloride.The structure of the compound was confirmed by ~1H NMR,^（13）C NMR etc.The target product was identified as ~1H-imidazole-4-carbonitrile.The overall yield of fructose was 33.5%in three steps.

关 键 词：果糖 环合 氧化 氰基化 盐酸羟胺 

分 类 号：O626.23[理学—有机化学] O657.2[理学—化学]