尼群地平磷脂超分子复合物的复合率测定  

Determination of Complexation Rate of Nitrendipine-Phospholipid Complex

作　　者：刘碧林[1] 谭群友[2] 陈峰杰[3] 朱照静[4] 张景勍[1] 

机构地区：[1]重庆医科大学药物高校工程研究中心和生物化学与分子药理学重点实验室,重庆市渝中区医学院路1号400016 [2]第三军医大学大坪医院野战外科研究所胸外科 [3]重庆医科大学附属第一医院药剂科 [4]重庆医药高等专科学校

出　　处：《光谱实验室》2012年第1期174-177,共4页Chinese Journal of Spectroscopy Laboratory

基　　金：教育部博士点基金资助项目(20095503120008);重庆市教育委员会资助项目(首批高等学校优秀人才资助;KJ090308)

摘　　要：建立尼群地平磷脂超分子复合物的复合率测定方法。采用紫外分光光度法测定尼群地平磷脂超分子复合物中复合了的药物含量,从而计算复合率。结果表明,尼群地平在237nm处有最大吸收,浓度在2.18—10.89μg·mL^(-1)范围内与吸光度呈良好的线性关系,回归方程为:A=0.0760C+0.0013,r=0.9999;平均加标回收率为99.3%,RSD为1.2%(n=9)。该法简便、快速,重现性好,结果准确可靠。A new method for determination of complexation rate of nitrendipine-phospholipid complex was established.The nitrendipine entrapped in nitrendipine-phospholipid complex was determined by UV-visible spectrophotometry,then the complexation rate was calculated.The results showed that the concentration of nitrendipine had a good linear relationship in the range of 2.18—10.89μg · mL^（-1）with adsorption.The regression equation was as follow：A = 0.0760C ＋ 0. 0013,r=0.9999.The average recovery rate was 99.3%,RSD was 1.2%（n=9）.The method was simple and fast with good repeatability and results.

关 键 词：尼群地平 磷脂超分子复合物 复合率 

分 类 号：O657.32[理学—分析化学]