液相色谱-串联质谱法测定小型家用电器塑料部件中双酚A  

Determination of bisphenol A in plastic parts of small household appliances by liquid chromatography-tandem mass spectrometry

作　　者：张岩[1] 马晓斐 吕品[2] 李挥 卢晓宇[3] 

机构地区：[1]河北省食品质量监督检验研究院,河北石家庄050091 [2]河北医科大学,河北石家庄050017 [3]北京出入境检验检疫局,北京100026

出　　处：《色谱》2012年第1期95-98,共4页Chinese Journal of Chromatography

基　　金：国家质检总局科技计划项目(2009IK100)

摘　　要：建立了小型家用电器塑料部件中双酚A的液相色谱-串联质谱(LC-MS/MS)检测方法。采用快速溶剂萃取仪对样品进行萃取,以Sep-Pak C18固相萃取柱净化,甲醇-水(含有0.05%氨水)混合液作为流动相,负离子模式下进行MS/MS检测。结果表明:该方法在5～100μg/L范围内线性关系良好,相关系数(r2)为0.999 1。在10、25和75μg/kg 3个添加水平下,双酚A的平均回收率为95.2%～109.7%,相对标准偏差均小于3.8%,检出限为10μg/kg。该方法操作简便,灵敏度高,适用于家用电器塑料部件中双酚A的残留分析。A method for the determination of bisphenol A in the plastic parts of small household appliances by liquid chromatography-tandem mass spectrometry（LC-MS/MS） was developed.The sample was extracted with accelerated solvent extraction（ASE） and purified by Sep-Pak C18 solid phase extraction.Bisphenol A was separated and detected using LC-MS/MS in negative ion mode with the mobile phases of methanol and water（containing 0.05% ammonia water）.The linearity of the method was good in the range of 5 μg/L to 100 μg/L.The recoveries for the spiked sample were from 95.2% to 109.7% at the three levels,10,25 and 75 μg/kg.The relative standard deviations were less than 3.8%.The limit of detection was 10 μg/kg.The method is easy-handling,time-saving,sensitive and suitable for the determination of the residual bisphenol A in the plastic parts of household appliances.

关 键 词：液相色谱-串联质谱 固相萃取 双酚A 塑料部件 家用电器 

分 类 号：O658[理学—分析化学]