血清血管生成因子预测子痫前期患病风险的价值  

The value of serum angiogenic factors for predicating development of preeclampsia

作　　者：袁小松[1] 张一鸣[1] 蒋丽霞[1] 魏梓雯[1] 

机构地区：[1]南京医科大学附属常州市妇幼保健院检验科,江苏省213003

出　　处：《江苏医药》2012年第1期40-42,共3页Jiangsu Medical Journal

基　　金：常州市卫生局规划项目(WZ201028)

摘　　要：目的探讨中期妊娠血清可溶性血管内皮生长因子受体1(sFlt-1)、可溶性内皮因子(sEng)及胎盘生长因子(PLGF)水平预测子痫前期的价值。方法用ELISA检测子痫前期(A组,57例)和正常妊娠(B组,43例)孕妇妊娠中期血清sFlt-1、sEng和PLGF水平。结果 A组血清sFlt-1、sEng浓度高于B组,血清PLGF浓度低于B组(P<0.01);A组sFlt-1、sEng与PLGF水平分别呈负相关,sFlt-1与sEng水平呈正相关(P<0.01)。在妊娠中期,sFlt-1/PLGF比值>1.9时,预测子痫前期的敏感性为89.5%,特异性88.4%;sEng/PLGF比值>15.6,预测子痫前期的敏感性为84.2%,特异性86.1%;(sEng+sFlt-1)/PLGF比值>16.9,预测子痫前期的敏感性为93.0%,特异性为95.3%。结论妊娠中期检测血清sFlt-1、sEng和PLGF水平可有助于预测子痫前期。Objective To investigate the value of serum angiogenic factors for predicating development of preeclampsia during the second trimester. Methods Serum soluble fms-like tyrosine kinase-1（sFlt-1）,soluble endoglin（sEng） and placenta growth factor（PLGF） were detected using ELISA in 57 preeclampsia pregnant women（group A） and 43 pregnat women without preeclampsia（group B）. Results Serum levels of sFlt-1 and sEng were significantly higher,but serum PLGF was lower,in Group A than those in group B（P0.01）.Serum sFlt-1 and sEng were negatively correlated with PlGF,and sFlt-1 was positively correlated with sEng in group A（P0.01）.As early markers for predicting the development of preeclampsia in the second trimester,the ratio of sFlt-1/PLGF1.9,sEng/PLGF15.6,and（sEng＋sFlt-1）/PLGF16.9 showed the sensitivity and specificity of 89.5% and 88.4%,88.4% and 86.1%,and 93.0% and 95.3%,respectively. Conclusion In the second trimester,detection of serum sFlt-1,sEng and PLGFP is helpful in predicting the development of preeclampsia.

关 键 词：胎盘生长因子 血管内皮生长因子受体1 可溶性内皮因子 子痫前期 

分 类 号：R392[医药卫生—免疫学]