实时超声弹性成像诊断肝纤维化的价值  

Application Value of Real-time Ultrasound Elastography on the Diagnosis of Liver Fibrosis

作　　者：陈曦[1] 解丽梅[1] 董颖慧[1] 广旸[1] 张晓雯[1] 

机构地区：[1]中国医科大学附属盛京医院超声科,沈阳110004

出　　处：《中国医科大学学报》2012年第1期62-64,共3页Journal of China Medical University

基　　金：辽宁省自然科学基金资助项目(20102268)

摘　　要：目的探讨实时超声弹性成像(RTE)定量评价慢性病毒性肝炎肝纤维化的价值。方法对88例慢性病毒性肝炎患者进行RTE扫查,测量肝组织/肋间肌肉组织的应变比,并与肝组织活检结果进行对照。结果 RTE应变比结果与肝纤维化病理分期具有明显的负相关性(Spearman相关系数r=-0.815,P<0.01),肝纤维化各期RTE应变比组间差异有统计学意义(P<0.01),随着肝纤维化程度的加重,RTE应变比也随之下降。以病理结果S≥2期作为诊断明显肝纤维化的标准,RTE应变比受试者工作特征曲线下面积为0.927,得到应变比1.10为最佳诊断界值。其诊断肝纤维化的敏感度为86.84%、特异度为82.00%。结论 RTE为无创、定量诊断肝纤维化程度提供了新方法,在临床中有着良好的应用前景。Objective To investigate the value of real-time ultrasound elastography in diagnosing chronic viral hepatitis caused liver fibrosis quantitatively. Methods 88 patients were scaned with RTE who suffered chronic viral hepatitis, the elastic strain ratio of liver tissue to muscle tissue was measured and compared with pathology via liver biopsy. Results A negative correlation between the elastic ratio and the histological fibrosis stages （Spearman＇s correlation coefficient r =-0.815 ,P 〈 0.01 ） was detected. In RTE ,a high correlation of decreasing elastic strain ratio with inereasing stage of fibrosis was observed （P 〈 0.01 ）. As the severity of hepatic fibrosis,the values of elastic strain ratio were declining. With pathological results of S ≥2 as a diagnostic significant fibrosis standards, the area under receiver operating characteristic curve of elastic strain ratio was 0.927 . The best diagnosis boundary value was 1,10. The sensitivity atad specificity of RTE for diagnosing significant liver fibrosis was 86.84 % and 82.00 %,respectively. Conclusion RTE measuring provided a new method for diagnosing liver fibrosis degrees non-invasively, quantitatively and will have good application prospect in the clinical practice.

关 键 词：超声弹性成像 肝穿活检 肝纤维化 

分 类 号：R445.1[医药卫生—影像医学与核医学]