中国健康成人丘脑体积与年龄的相关性  

Correlation between the thalamic volume and age of the healthy Chinese adults

作　　者：马帅[1] 陈楠[2] 秦媛[1] 王星[2] 卓彦[3] 陈霖[3] 郭玉林[4] 李坤成[2] 

机构地区：[1]宁夏医科大学临床医学院,宁夏银川750004 [2]首都医科大学宣武医院放射科,北京100053 [3]中国科学院生物物理研究所脑与认知科学国家重点实验室,北京100101 [4]宁夏医科大学总医院放射科,宁夏银川750004

出　　处：《中国医学影像技术》2012年第1期19-22,共4页Chinese Journal of Medical Imaging Technology

基　　金：国家高技术研究发展计划(863计划)项目(2006AA02z391);国家重点基础研究发展计划(973计划)项目(2005CB522800;2004CB318101);国家自然科学基金(30621004;30870697)

摘　　要：目的测量1000名中国健康成人丘脑体积,分析丘脑体积与年龄的相关性,为临床诊断丘脑病变提供依据。方法从全国不同地区选择健康汉族成人志愿者1000名,按年龄分为5组：18~30、31~404、1~50、51~606、1~80岁组,每组200名,男、女各半。采用1.5T MR采集图像,应用Aquariusws软件手动逐层勾画出丘脑边界,软件自动测算出其体积。分析丘脑体积与年龄之间的相关性及不同年龄段之间丘脑体积的差异。结果 18~30、31~40、41~50、51~60、61~80岁组右侧丘脑体积正常值范围分别为（6069.38±531.90）mm3、（5894.67±538.93）mm3、（5357.43±479.97）mm3、（5396.08±445.58）mm3、（4791.44±558.15）mm3,左侧丘脑体积正常值范围分别为（6179.82±534.29）mm3、（6046.97±561.83）mm3、（5425.67±470.90）mm3、（5551.65±526.47）mm3、（4866.00±551.73）mm3。分别比较各年龄组间左侧和右侧丘脑体积,除18~30岁与31~40岁、41~50岁与51~60岁年龄组差异无统计学意义外,其余各组间差异均有统计学意义（P均〈0.05）。左、右侧丘脑体积均与年龄呈负相关（r=-0.63、-0.65,P〈0.05）。结论丘脑体积与年龄呈负相关,即随着年龄增大,丘脑体积逐渐减小。Objective To measure thalamic volume of 1000 healthy Chinese adults,and to analyze the relationship between thalamic volume and age,in order to provide evidence of clinical diagnoses for thalamic diseases.Methods Totally 1000 healthy Chinese adults of Han nationality aged from 18 to 80 years were selected and divided into 5 groups by age： 18—30,31—40,41—50,51—60 and 61—80 years.Each group included 200 subjects composed of half male and half female.Brain images were obtained with a 1.5T MR,and outline of the thalamic was drawn with Aquariusws software.Then the thalamic volume was calculated automatically.The relationship between thalamic volume and age,and the differences between each two groups were analyzed respectively.Results The right thalamic volume of 18—30,31—40,41—50,51—60 and 61—80 year-old group was（6069.38±531.90）mm3,（5894.67±538.93）mm3,（5357.43±479.97）mm3,（5396.08±445.58）mm3 and（4791.44±558.15）mm3,respectively,while the left thalamic volume was（6179.82±534.29）mm3,（6046.97±561.83）mm3,（5425.67±470.90）mm3,（5551.65±526.47）mm3,（4866.00±551.73）mm3,respectively.Except 18—30 and 31—40,41—50 and 51—60 year-old group,statistical differences of thalamic volume were found between each other two groups in both sides（all P0.05）.The left and right thalamic volume were all negatively correlated with age（r=-0.63,-0.65,P0.05）.Conclusion There is significantly negative correlation between the thalamic volume and age.The thalamic volume decreases while the age grows.

关 键 词：丘脑 人体测量术 磁共振成像 年龄 

分 类 号：R445.2[医药卫生—影像医学与核医学] R32[医药卫生—诊断学]