树突状细胞在银屑病致病机制中作用的研究进展  

The research progress in the role of dendritic cells in psoriasis pathogenesis

作　　者：王燕[1] 赵京霞[1] 刘欣[1] 李萍[1] 

机构地区：[1]北京市中医研究所,北京100010

出　　处：《基础医学与临床》2012年第1期96-98,共3页Basic and Clinical Medicine

基　　金：国家自然科学基金(81072810)

摘　　要：银屑病是多种因素造成的T细胞异常活化的慢性炎性反应皮肤病,最新研究表明,在T细胞被激活前,树突状细胞(DCs)的活化才是银屑病发生的起始和关键。正是因为DC数量增多、刺激T细胞能力增强、分泌多种细胞因子及化学增活素,形成"细胞因子风暴",从而导致银屑病的红斑。Psoriasis is a chronic inflammation of skin caused by abnormal activation of T cells. Recent research shows that before the T cells are activated, the activation of Dendritic Cells （DCs） is the early-phase and pivotal process in the occurrence of psoriasis. Just because the quantity of DCs increase, their ability of stimulating T cells enhances and they secrete multiple cytokines which form the＂cytokine storm＂ that leads to the erythema of psoriasis.

关 键 词：树突状细胞 银屑病 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]