秋水仙碱在皮肤病治疗中的进展  

Colchicine in the treatment of dermatoses

作　　者：宋亚丽[1] 金德蕙[1] 周淑华[1] 

机构地区：[1]山东大学附属省立医院皮肤科,济南250021

出　　处：《国际皮肤性病学杂志》2012年第1期63-66,共4页International Journal of Dermatology and Venereology

基　　金：山东省医药卫生科技发展计划（2009QZ019）;山东省自然科学基金（Y2007C041）

摘　　要：秋水仙碱为一天然产物，自百合科植物秋水仙中提取，其应用于临床历史悠久，具有抗有丝分裂、抗炎症、免疫抑制作用。痛风和家族性地中海热是秋水仙碱的绝对适应证，近年来在临床应用中发现，秋水仙碱治疗某些特定皮肤病，如某些中性粒细胞浸润性皮肤病、银屑病、大疱性皮肤病等有良好的疗效。秋水仙碱低剂量时一般耐受良好，不良反应少，但过量使用时毒副作用较多，因此，临床应用时需注意药物的不良反应及药物间的相互作用，并及时监测相关指标。Colchicine, a toxic natural product and the active principle of Colchicum autumnale, has been known since antiquity for its medicinal uses. It possesses anti-mitotic, anti-inflammatory and immunosuppressive activities. There are two non-dermatologic absolute indications of colchicine： acute gout crisis and familial Mediterranean fever. Several uncontrolled clinical studies have shown exciting outcomes in the treatment of some dermatologic diseases with colchieines, such as neutrophilic dermatoses, psoriasis, bullous dermatoses, and so on. Low dose of colchicine is well tolerable with less adverse reactions, while large dose of colchicine is associated with considerable toxic and side effects. Hence, attention should be paid to adverse reactions and drug interactions as well as relevant parameters during the clinical application of colchicines.

关 键 词：秋水仙碱 药理作用 皮肤疾病 

分 类 号：R751[医药卫生—皮肤病学与性病学]