他达拉非对Ⅲ型前列腺炎相关的性功能障碍的干预研究  

SIntervention Study of Tadalafil for Prostatitis-related Sexual Dysfunction

作　　者：刘贤奎[1] 董潇[1] 于鸿远[1] 崔小鲁[1] 孔垂泽[1] 

机构地区：[1]中国医科大学附属第一医院泌尿外科,辽宁沈阳110001

出　　处：《医学临床研究》2011年第12期2242-2244,共3页Journal of Clinical Research

摘　　要：[目的]探讨他达拉非对Ⅲ型前列腺炎相关的性功能障碍的治疗价值.[方法]选择符合美国国立卫生研究院（NIH）诊断标准的伴有性功能障碍的Ⅲ型前列腺炎患者210例,随机分为对照组70例,采用抗生素或α受体阻滞剂等常规治疗;干预组A组70例,在对照组基础上加用他达拉非口服治疗;干预B组70例,在对照组基础上加用复方玄驹胶囊口服治疗.应用慢性前列腺炎症状指数（CPSI）评分、前列腺炎相关的性功能障碍评分表（PSFI）评分和焦虑自评量表（SAS）评分进行治疗前后的结果分析.[结果]前列腺炎相关的性功能障碍与前列腺炎症状程度无相关性（r=0.103,P＞0.05）.治疗后他达拉非及复方玄驹胶囊干预组前列腺炎症状及性功能改善程度明显优于对照组（P＜0.01,P＜0.05）,两干预组间对比,他达拉非组明显优于复方玄驹组,差异有统计学意义（P＜0.05）;焦虑评分值干预组明显低于对照组（P＜0.05）.[结论]他达拉非和复方玄驹胶囊可以明显改善Ⅲ型前列腺炎患者相关的性功能障碍及与之相关的其他症状,并且可以改善伴随的焦虑症状,他达拉非的疗效更好.[Objective]To explore the value of tadalafil in the treatment of type III prostatitis-related sexual dysfunction. [Methods]Totally 210 cases of type III chronic prostatitis with sexual dysfunction diagnosed by NIH clinical criteria were randomly divided into control group, intervention A group and intervention B group with 70 eases in each group. Control group received routine therapy with antibiotics or alpha-receptor blockers. Intervention A group was additionally treated with oral tadalafil based on the treatment of control group. Intervention B group was additionally treated with oral Fufangxuanju capsule based on the treatment of control group. ChroMe prostatitis symptom index（CPSI） score, sexual dysfunction symptom index（PSFI） score and anxiety symptoms index（SAS） score were used to analyze the results before and after treatment. [Results] The degree of prostatitis-related sexual dysfunction was not correlated with that of prostatitis symptoms（r= 0. 103, P 〉0.05）. The improvement of prostatitis symptoms and sexual function in the groups of tadalafil and Fufangxuanju capsule were better than those in control group（ P 〈0.01, P 〈0.05）. The improvement of prostatitis symptoms and sexual function in tadalafil group was obviously better than that in Fufangxuanju capsule group, and the difference between two groups also had statistical significance（ P 〈0.05）. The anxiety scores in intervention groups were obviously lower than those in control group （ P 〈 0. 05）. [Conclusion] Tadalafil and Fufangxuanju capsule can not only improve type III prostatitis-related sexual dysfunction and other related symptoms, but also alleviate the accompanying anxiety symptoms. The curative effect of tadalafil is better.

关 键 词：前列腺炎/并发症 性功能障碍/药物疗法 

分 类 号：R698[医药卫生—泌尿科学]