碳／碳复合材料的生物学安全性评价研究  

Biological safety evaluation of Carbon-Carbon composites

作　　者：倪昕晔[1] 汤晓斌[1] 林涛[2] 耿长冉[1] 宋浩磊[2] 刘茜[2] 蔡雷铭[2] 顾卫东[2] 陈达[1] 

机构地区：[1]南京航空航天大学材料科学与技术学院,210016 [2]南京医科大学附属常州第二人民医院,213003

出　　处：《国际生物医学工程杂志》2011年第6期340-343,I0010,共5页International Journal of Biomedical Engineering

基　　金：江苏省常州市社会发展项目（CS20102019）,南京航空航天大学基础科研业务费专项科研项目（Y1065-0630）

摘　　要：目的探讨碳，碳复合材料的生物学安全性。方法依据中华人民共和国国家标准对医疗器械生物学评价的要求，对碳／碳复合材料进行细胞毒性试验、急性全身毒性试验、溶血试验、热源试验、肌肉植入试验等生物学安全性评价研究。结果碳／碳复合材料的各项生物学性能指标符合国家标准要求，无细胞毒性和全身毒性、无热源性，具有良好的生物相容性。结论碳，碳复合材料可以应用到临床医学中。Objective Due to the superior performance, Carbon-Carbon composites, although still at their early stage of development, have gained more and more attention and showed great application potential. Methods According to the National Standard, the biological safety evaluation of carbon-carbon composites were done in the following aspects： cytotoxicity test, acute systemic toxicity test, haemolysis test, pyrogen test, intramuscular implantation test. Results test results showed the biological safety evaluation of carbon-carbon composites well meet the requirement of the national standard with fine biological compatibility. Conclusion The experiment results demonstrate that carbon-carbon composites can be put in clinical application

关 键 词：碳/碳复合材料 生物学安全评价 毒性 试验 

分 类 号：R318.08[医药卫生—生物医学工程]