胸腺五肽对复发性外阴阴道念珠菌病患者IL-12p70和IL-23p19水平的影响及疗效分析  

Therapeutic Effect of Thymopentin on IL-12p70 and IL-23p19 Level in Patients with Recurrent Vulvovaginal Candidiasis

作　　者：喻楠[1] 夏毓[2] 尚元元[1] 董灵娣[1] 

机构地区：[1]宁夏医科大学总医院皮肤科,银川750004 [2]甘肃省张掖市人民医院皮肤科,张掖734000

出　　处：《宁夏医科大学学报》2011年第11期1029-1032,共4页Journal of Ningxia Medical University

基　　金：宁夏卫生厅重点科研计划项目(W200320)

摘　　要：目的研究观察胸腺五肽对复发性外阴阴道念珠菌病患者阴道分泌物IL-12p70和IL-23p19水平的影响及疗效。方法采用酶联免疫吸附实验(ELISA)双抗体夹心法检测复发性外阴阴道念珠菌病患者治疗组、对照组治疗前后及正常人阴道分泌物IL-12p70和IL-23p19水平。结果两组治疗前复发性外阴阴道念珠菌病患者IL-12p70和IL-23p19水平均低于正常人(P<0.01),两组患者间IL-12p70和IL-23p19水平相近(P>0.05)。治疗后胸腺五肽组IL-12p70和IL-23p19水平升高,对照组治疗前后水平差异无统计学意义(P>0.05)。治疗组的疗效(总有效率80.00%)明显高于对照组的43.33%(P<0.05)。结论复发性外阴阴道念珠菌病患者存在着Th1/Th2型细胞因子失衡,胸腺五肽可通过纠正两型细胞因子失衡而改善患者免疫功能,提高治疗效果。Objective To observe therapeutic effect of thymopentin on IL-12p70 and IL-23p19 level and in patients with recurrent vulvovaginal candidiasis.Methods 80 subjects were divided into three groups,namely treatment group,control group and healthy group.IL-12p70 and IL-23p19 level in normal people and the patients of recurrent vulvovaginal candidiasis were detected by enzyme-linked immunosorbent assay-Double-antibody sandwich method before and after treatment.Results IL-12p70 and IL-23p19 levels in pretherapeutic patients with recurrent vulvovaginal candidiasis were significantly lower than those of healthy group,the two groups of patients had the similar level of IL-12p70 and IL-23p19（P〉0.05）.After treatment,the level of IL-12p70 and IL-23p19 in group with thymopentin increased significantly compared with control group（P〈0.01）.The therapeutic effect of treatment group（total effective rate：80.00%） was significantly higher than that of control group（total effective rate：43.33%）（P〈0.05）.Conclusion There exists imbalance of Th1/Th2 cell factors in the patients with recurrent vulvovaginal candidiasis.Thymopentin can improve the patients＇ immunologic function and enhance the therapeutic effect by rectify the imbalance of the two type of cell factors.

关 键 词：复发性外阴阴道念珠菌病 胸腺五肽 IL-12p70 IL-23p19 

分 类 号：R711.3[医药卫生—妇产科学]