多烯磷脂酰胆碱与10种临床常用药物配伍稳定性观察  

Compatibility of Polyene Phosphatidylcholine and 10 Drugs in Common Use

作　　者：刘晓鸿[1,2] 张明生[3] 

机构地区：[1]安徽医科大学第三附属医院 [2]合肥市第一人民医院药学部,安徽合肥230061 [3]安徽中医学院第一附属医院药学部,安徽合肥230031

出　　处：《中国药物警戒》2012年第2期69-71,共3页Chinese Journal of Pharmacovigilance

摘　　要：目的观察多烯磷脂酰胆碱与10种临床常用药物配伍稳定性。方法将多烯磷脂酰胆碱葡萄糖注射液与10种药物葡萄糖注射液等体积混合,观察混合液澄明度并测pH值;将多烯磷脂酰胆碱与8种药物直接等体积配伍,观察澄明度。结果多烯磷脂酰胆碱葡萄糖注射液与维生素B6葡萄糖注射液、氨甲苯酸葡萄糖注射液混合p,H值低于6.5,并产生浑浊;多烯磷脂酰胆碱直接与利巴韦林、维生素C、胃复安、维生素K1注射液等体积混合后,产生浑浊。结论多烯磷脂酰胆碱与维生素B6、氨甲苯酸、利巴韦林、维生素C、胃复安、维生素K1存在配伍禁忌。Objective To observe the compatibility of polyene phosphatidylcholine and 10 other drugs in common usage. Methods To mix isopyknic polyene phosphatidylcholine glucose injection with 10 other drugs and pharmic glucose injections and observe the clarity of the mixtures and test their pH values; to directly mix isopyknic polyene phos- phatidylcholine injection and 8 other injections and observe their clarity. Results Mixtures ofpolyene phosphatidylcholine glucose injection with vitamin B6 ant glucose injection and aminomethyl benzoic acid and glucose injection are muddy and their PH values are lower than 6.5; Mixtures of isopyknic polyene phosphatidylcholine and ribavirin, vitamin C, metoclopramide dihydrochloride and vitamine K1 are muddy. Conclusion Polyene phosphatidylcholine is incompatible with vitamin B6, aminomethylbenzoic acid, ribavirin, vitamin C, metoclopramide dihydrochloride and vitamin K1.

关 键 词：多烯磷脂酰胆碱 配伍稳定性 常用的 

分 类 号：R975.5[医药卫生—药品] R969.2[医药卫生—药学]