万古霉素致白细胞减少症38例回顾性分析  

Retrospective Analysis of 38 Granulocytopenia Cases Induced by Vancomycin

作　　者：刘丽英 李勇[2] 古淑仪[3] 

机构地区：[1]江西省于都县人民医院,江西于都342300 [2]北京军区总医院,北京100700 [3]广州市红十字会医院,广东广州510220

出　　处：《中国药物警戒》2012年第2期117-118,共2页Chinese Journal of Pharmacovigilance

摘　　要：目的研究万古霉素致白细胞减少的临床特点。方法收集2006年1月～2011年6月我院发生的38例病例患者的临床资料,并对其年龄、性别、用药情况、出现白细胞减少症的临床表现及预后进行分析。结果 38例患者中男26例(68.42%),女12例(31.58%)。年龄16～71岁,平均年龄39.66±9.86岁。使用万古霉素的疗程7～27天,白细胞值最低的为0.49×109/L,所有病例均在出现白细胞减少时停用万古霉素,有6例给予升白细胞药,有32例未做其他特殊处理,2～7天后38例患者白细胞及中性粒细胞均得到恢复。结论万古霉素引起的白细胞减少症是可逆的,但在此期间发生合并感染的风险增加,故临床仍要引起高度重视。Objective To study the clinical traits of granulocytopenia induced by vancomycin. Methods Clinical in- formation of 38 granulocytopenia cases at our hospital fi：om jaunary to june in 2006 was collected, and age, gender, medication, clinical manifestation of granulocytopenia and prognosis were analyzed. Results 26 patients（68.42%） were male in 38 cases and 12 were female（31.58%）. The average age was 39.66±9.86 years old. The course of treatment by vancomycin was 7~27 days. The minimum of leucocytes count was 0.49 ×10^9/L. Vancomycin withdrawal was adopted in all patients, among whom 6 patients received drugs to elevate leucocytes and 32 patients not received any special treatments. All patients＂ leucocytes and neutrophils returned to normal ranges after 2~7 days. Conclusion Granulocytopenia induced by vancomycin is reversible, whereas the risk of concurrent infection is increased, which should be paid much attention to.

关 键 词：万古霉素 不良反应 白细胞减少 

分 类 号：R978[医药卫生—药品] R994.11[医药卫生—药学]