诱导排痰检查对阻塞性气道疾病中的应用分析  

The clinical significance and application of cytological examination of induced sputum in chronic airway disease

作　　者：陈华萍[1] 吴颖[1] 万敏[1] 张巧[1] 马千里[1] 王关嵩[1] 王长征[1] 

机构地区：[1]第三军医大学新桥医院呼吸内科,重庆400037

出　　处：《重庆医学》2012年第1期14-15,18,共3页Chongqing medicine

摘　　要：目的探索诱导排痰检查在阻塞性气道疾病中的临床意义。方法选择慢性咳嗽患者65例,其中男20例,女45例,平均年龄(47±15)岁;哮喘患者80例,男29例,女51例,平均年龄(48±14)岁;慢性阻塞性肺疾病(COPD)患者68例,男46例,女22例,平均年龄(66±10)岁。进行诱导痰细胞学检查。结果 20.00%(13/65)的慢性咳嗽患者诱导痰中嗜酸性细胞(EOS)百分比大于3%,提示考虑嗜酸细胞性支气管炎的可能;哮喘组中EOS和中性粒细胞(NEU)的平均百分比分别为(4.62±3.51)%和(42.59±23.90)%,其中83.7%(67/80)的患者,EOS>1%,25.0%(20/80)的患者NEU>61%;COPD患者EOS和NEU的平均百分比分别为(0.80±0.80)%和(54.43±21.51)%,其中29.4%(24/68)EOS>1%,55.8%(38/68)NEU>61%,在哮喘组和COPD组间EOS和NEU比例比较差异有统计学意义(P<0.01)。结论诱导排痰细胞学检查可对慢性咳嗽的鉴别诊断和判断哮喘、COPD气道炎症具有重要的指导意义。Objective To explore the clinical value of cytological examination of induced sputum in chronic airway disease.Methods Sixty five cases（age：47±15 yr） with chronic cough were enrolled,including 20 males and 45 females.Eighty cases（age：48±14 yr） with asthma were enrolled,including 29 males and 51 females.Sixty eight cases（age：66±10 yr） with COPD were enrolled,including 46 males and 22 females.Results The percentage of those patients whose EOS above 3% was 20%（13/65） in patients with chronic cough.These patients were considered to be suffered from eosinophilic bronchitis.The means of EOS and NEU percentages in asthma patients were（4.62±3.51）% and（42.59±23.90）%.Among these cases,the percentage of those patients whose EOS above 1% was 83.7%（67/80） and NEU was over 61% was 25.0%（20/80） in patients with asthma.The EOS and NEU percentages mean in COPD patients were（0.80±0.8）% and（54.43±21.51）%.The percentage of those patients whose EOS above 1% was 29.4%（24/68 and NEU above 61% was 55.8%（38/68） in patients with asthma.For EOS and NEU percentages,there was markedly difference between asthma group and COPD group（P〈0.01）.Conclusion The cytological examination in induced sputum may be meaningful for differential diagnosis of chronic cough and treatment of asthma and COPD.

关 键 词：肺疾病 慢性阻塞性 诱导排痰细胞学检查 慢性咳嗽 哮喘 

分 类 号：R563.9[医药卫生—呼吸系统]