肌钙蛋白I、高敏C反应蛋白在非ST段抬高急性冠脉综合征中的临床意义  

Clinical significance of serum troponin I,highly sensitive c-reactive protein to the non hs-up to ST acute coronary syndromes

作　　者：冉瑞明[1] 陈平[1] 康忠明[1] 史光东[1] 

机构地区：[1]重庆三峡中心医院平湖分院综合医疗科,重庆万州404000

出　　处：《重庆医学》2012年第1期38-39,共2页Chongqing medicine

摘　　要：目的探讨血清肌钙蛋白I(cTnI)、高敏C反应蛋白(hs-CRP)对非ST段抬高急性冠脉综合征(NSTEACS)患者临床分型和危险度分层的应用价值。方法用化学发光免疫法、免疫比浊法对86例NSTEACS患者和45例正常健康者血清cTnI、hs-CRP测定,并选择性地行128层螺旋CT冠状动脉造影术。结果 hs-CRP在非ST段抬高心肌梗死(NSTEMI)组和不稳定型心绞痛(UA)组较对照组明显增高(P<0.05);NSTEMI组与UA组比较差异无统计学意义(P>0.05)。cTnI在NSTEMI组、UA组及对照组间比较,差异有统计学意义(P<0.05)。cTnI阳性组的冠状动脉重度病变明显多于cTnI阴性组(P<0.01)。结论 hs-CRP对NSTEACS患者早期危险性有预测价值,cTnI对NSTEACS患者临床分型及危险度分层有指导意义,并可作为评估冠状动脉病变严重程度的重要指标。Objective To explore application value of serum muscle calcium protein I（cTnI）、 highly sensitive c-reactive protein（CRP） to the NSTEACS in the clinical classification and risk stratification.Methods Using chemical luminescence immunoassay method and immunoassay turbidity method to test the concentration of serum cTnI and hs-CRP in 86 NSTEACS patients and 45 normal healthy persons,and selectively using 128-layer spiral CT to conduct coronary angiography.Results The levels of hs-CRP in the non ST-escalating myocardial infarction（NSTEMI） group and unstable angina（UA） group were significantly higher than those in the control group（P〈0.05）.NSTEMI group and UA group had no significant difference（P〈0.05）.Comparisons in the levels of cTnI in NSTEMI group,UA group and control group all have significant difference（P〈0.05）.Lesions in CTnI positive group of coronary artery was obviously severe than those in cTnI negative group（P〈0.01）.Conclusion The hs-CRP has early risk predictive value to NSTEACS patients,cTnI has the guiding significance to clinical classification and risk stratification,and can be used as an important index in the evaluation of coronary artery disease severity.

关 键 词：肌钙蛋白I C反应蛋白质 冠状动脉疾病 危险性评估 

分 类 号：R541.4[医药卫生—心血管疾病]