大疱性表皮坏死松解型药疹致疹药物文献分析  

Analysis of literature on allergizing drugs of bullous epidermolytic necrotic drug eruption

作　　者：陈勇彬[1] 

机构地区：[1]深圳市宝安区人民医院社康科,广东518000

出　　处：《中国临床新医学》2012年第1期27-30,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

摘　　要：目的了解引发大疱性表皮坏死松解型药疹的药物致疹发生频率。方法收集1989～2011年文献中有关大疱性表皮坏死松解型药疹的报道病例,对致疹药物进行统计,并分析致疹药物的不良反应发生率,推算大疱性表皮坏死松解型药疹的发生率。结果统计表明,引发大疱性表皮坏死松解型药疹的药物品种有51种,阳性病例176例,抗感染药物涉及17种69例,神经精神类药物6种46例,解热镇痛药物4种28例。单一品种中卡马西平引发个案26例(发生率为5.04%),氨基比林引发个案18例(发生率为0.68%),苯巴比妥和阿莫西林各9例(发生率分别为1.24%和0.37%)。结论引发大疱性表皮坏死松解型药疹的药物以抗生素类药物、神经精神类药物和解热镇痛类药物常见,致疹发生率较高的药物有卡马西平、苯妥英钠、别嘌醇和扑热息痛等。Objective To investigate the inducing rash frequency of allergizing drugs of bullous epidermolytic necrotic drug eruption. Methods Relevant cases from referential articles were reviewed, allergizing drugs were calculated, and the incidence rates of bullous epidermolytic necrotic drug eruption were calculated by collecting the incidence rates of adverse reactions caused by allergizing drugs. Results There were 51 kinds of drugs that caused bullous epidermolytic necrotic drug eruption, among 176 positive cases, there were 69 cases related to 17 anti-infective drugs, 46 cases related to 6 neuropsychiatric drugs, 28 cases related to 4 antipyretic analgesics. 26 eases related to carbamazepine alone （an incidence rate of 5.04% ）, 18 cases related to aminopyrine （an incidence rate of 0. 68% ）, 9 eases for each of phenobarbital and amoxicillin （ incidence rates of 1.24% and 0. 37% respectively）.Conclusion Anti-infective drugs, neuropsychiatric drugs, and antipyretic analgesics are common drugs that trigger bullous epidermolytic necrotic drug eruption, while carbamazepine, phenytoin sodium, aUopurinol and paracetamol are high in incidence rate of causing drug eruption.

关 键 词：大疱性表皮坏死松解型药疹 不良反应发生率 

分 类 号：R758.25[医药卫生—皮肤病学与性病学]