补肾壮骨胶囊对兔膝骨关节炎软骨ADAMTS-4表达的影响  

Effects of Bushenzhuanggu Capsule on Rabbit Knee Osteoarthritis Chondrocytes ADAMTS-4 Expression

作　　者：张世华[1] 张学祥[2] 

机构地区：[1]山东省中医院,山东济南250014 [2]山东中医药大学,山东济南250014

出　　处：《辽宁中医药大学学报》2012年第2期7-8,共2页Journal of Liaoning University of Traditional Chinese Medicine

摘　　要：目的:观察补肾壮骨胶囊对兔膝骨性关节炎软骨细胞ADAMTS-4表达的影响。方法:将新西兰白兔40只分为A正常组、B模型组、C治疗组、D对照组,B、C、D 3组按照Hulth造模方法造成兔膝骨性关节炎模型。C组给予补肾壮骨胶囊,D组给予壮骨关节丸。给药8周后测定关节软骨ADAMTS-4阳性细胞数。结果:正常组软骨很少表达ADAMTS-4,模型组中的ADAMTS-4表达显著高于正常组(P<0.01),治疗组和对照组的ADAMTS-4表达显著低于模型组(P<0.01),但高于正常组(P<0.01)。结论:补肾壮骨胶囊抑制KOA软骨中ADAMTS-4的表达。Objective ： To observe effects of Bushenzhuanggu capsule （ BSZGC ） on rabbit knee osteoarthritis ehondrocytes ADAMTS-4 expression. Methods ： In the experiment study,40 New Zealand rabbits were randomly divided into 4 groups ： Group A （ the normal group ）, Group B （ the model group ）, Group C （ the treated group ）and Group D （the control group ）.KOA models were created in Group B, C and D by Huhh＇s operation methods. The rabbits in Group D were treated with Zhuangguguanjie pill （ ZGGJP ） and BSZGC was used in Group C. 8 weeks later, measured ADAMTS-4 positive cells of the rabbits articular cartilage. Results ： Normal cartilage rarely expressed ADAMTS-4, the model group of ADAMTS-4 expression was significantly higher than the normal group （P〈0.01）, treatment group and control group of ADAMTS-4 expression was significantly lower than model group （P〈0.01）, but higher than the normal group （P〈0.01）. Conclusion： Bushenzhuanggu capsule inhibit ADAMTS-4 expression of cartilage.

关 键 词：补肾壮骨胶囊 骨性关节炎 中医药治疗 实验研究 

分 类 号：R684.3[医药卫生—骨科学]