郁星菖志汤对脑卒中后抑郁大鼠脑组织NE、5-HT水平的影响  

Influence of Yuxing Changzhi Decoction on Levels of NE and 5-HT in Brain Tissue of Rats With Post-Stroke Depression

作　　者：洪杰斐[1] 李君良[1] 张兆强[1] 揭新明[1] 钟志国[1] 罗磊玲[1] 

机构地区：[1]广东医学院,广东湛江524001

出　　处：《辽宁中医药大学学报》2012年第2期9-10,共2页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：广东省中医药局资助项目(2008170)

摘　　要：目的:探讨中药郁星菖志汤对脑卒中后抑郁的作用机制。方法:建立脑卒中后抑郁大鼠模型,用酶联免疫法检测郁星菖志汤、氟西汀对受试大鼠脑组织NE、5-HT含量的影响。结果:模型组与空白对照组比较,NE、5-HT水平显著降低;郁星菖志汤组、氟西汀组与模型组比较,均有显著性差异(P<0.005);郁星菖志汤组与氟西汀组比较,无显著性差异(P>0.005)。结论:郁星菖志汤能显著提高脑卒中后抑郁大鼠脑组织NE、5-HT水平。Objective ： To explore the mechanism of Yuxing Changzhi decoction on treating post-stroke depression. Method ： To establish post-stroke depression model of rat, using ELISA to detect the influence of Yuxing Changzhi decoction on NE and 5-HT contents in brain tissue. Results ： Compared to control group, the NE and 5-HT levels in brain tissue is lower significantly in the model group; Yuxing Changzhi decoction group and fluoxetine group are different significantly than the control group （ P〈0.005 ）; Yuxing Changzhi decoction group is not different significantly than the Fluoxetine group （ P〉0.005 ） .Conclusion ： Yuxing Changzhi decoction can increase NE and 5-HT levels in the brain tissue on rats with post-stroke depression significantly.

关 键 词：脑卒中后抑郁 郁星菖志汤 NE 5-HT 

分 类 号：R285.5[医药卫生—中药学]