298例2型糖尿病对肺功能的影响  

Analysis of Pulmonary Function in 298 Patients with Diabetes Mellitus

作　　者：杨丹榕[1] 蒋鑫[2] 徐松翠[2] 隋大鸣[2] 白春学[3] 王桂芳[3] 

机构地区：[1]上海交通大学第六人民医院呼吸内科,上海200233 [2]第二军医大学附属长征临床医学院,上海200003 [3]复旦大学附属中山医院呼吸内科,上海200032

出　　处：《临床肺科杂志》2012年第2期198-200,共3页Journal of Clinical Pulmonary Medicine

基　　金：上海市重点学科建设项目(编号:B115)

摘　　要：目的分析糖尿病患者的肺功能,研究肺是否为糖尿病损害的靶器官。方法回顾性298名糖尿病患者肺功能(包括通气功能和弥散功能),以一氧化碳弥散量(DLCO)作为肺弥散功能的指标。对照组为年龄性别匹配的300名健康志愿者。分析糖尿病病程及合并高血压对肺功能的影响。结果糖尿病组患者中所有肺通气功能指标均低于对照组,但两组之间的差异均无统计学意义(P>0.05)。糖尿病患者DLCO平均值为91.4±16.7%,明显低于对照组(104.1±7.9%)(P<0.001)。结论糖尿病患者肺弥散功能受损,提示肺脏是糖尿病慢性病变的靶器官之一。Objective To evaluate pulmonary function in patients suffered from diabetes mellitus （DM） and to identify whether the lung was one of the target organs of chronic pathologic changes in DM. Methods Pulmonary function of 298 patients with DM and 300 healthy subjects were retrospectively investigated （ Pulmonary ventilation function and Diffusion of lung of CO, DLCO ）. DLCO was used as the indicator of diffusion capacity of lung. The relationship between DM＇s durations and lung function changes was analyzed and also the relationship between DM combined with blood pressure and lung function. Results Pulmonary ventilation function was reduced in patients with DM compared with the control group without significant differences （P 〉0. 05 ）. Although pulmonary diffusion capacity in patients with DM was in the normal range （91.4 ± 16. 7% ） ,it was significantly lower than that in the control group （P 〈0. 001 ）. There was no relationship between DM＇s durations and pulmonary diffusion capacity changes （F = 0. 439,P = 0. 508 ）. Pulmonary diffusion capacity in DM patients with hypertension was lower than that with normal blood pressure,without significant difference （P 〉 0. 05 ）. Pulmonary diffusion capacity was lower in patients with higher blood pressure,but there were no significant differences （ P 〉 0. 05 ）. Conclusion Impaired pulmonary function, especially diffusion capacity,is obvious in patients with DM. Lung is one of the target organs of chronic pathologic changes in DM.

关 键 词：糖尿病 肺功能 弥散功能 高血压 

分 类 号：R587.1[医药卫生—内分泌]