2003～2010年医院感染常见病原菌耐药分析  

Drug resistant trends of clinical isolates of pathogens in nosocomial infection during 2003～2010

作　　者：尹辛大 马爽[2] 国承杰 徐培军[1] 王世富[2] 张汝敏[2] 

机构地区：[1]淄博市中心医院呼吸科,山东淄博255036 [2]淄博市中心医院ICU,山东淄博255036 [3]淄博市中心医院检验科,山东淄博255036

出　　处：《临床肺科杂志》2012年第2期230-232,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的分析医院感染常见病原菌耐药性的变迁。方法对2003～2007年与2008～2010年两个时段病原菌多重耐药进行比较。结果多重耐药细菌的分离率逐年增加,后三年与前五年比较,耐亚胺培南的非发酵菌,产ESBLs的大肠埃希菌、肺炎克雷伯菌及耐甲氧西林的凝固酶阴性葡萄球菌均呈上升趋势(P<0.01)。8年间耐甲氧西林的金黄色葡萄球菌阳性率均高达90～100%,但后三年与前五年比较无显著变化(P>0.05)。结论病原菌的耐药形势日趋严重,坚持耐药性监测,对指导合理有效应用抗菌药物,积极控制细菌感染具有重要意义。Objective To analyze drug resistant trends of clinical isolates of pathogens, and to provide evidence for the rational use of antibiotics, prevention and control of hospital infection. Methods The drug resistance of the pathogens isolated from clinical specimens during 2003 -2010 were statistically investigated, and multi-drug resistance was farther analyzed in the first five years and the recent three years. Results Multi-drug resistant bacteria continuously increased. Non-fermentative bacteria resistaning to imipenem, Escherichia coli and Klebsiella pneumoniae and methicillin-resistant coagulase-negative Staphylococci gradually increased. There were significant differences between the first five years and the recent three years （P 〈 0. 01 ）. The isolation of methiciUin-resistant Staphylococcus anreus was very high during 2003 - 2010, and there was no significant difference between the first five years and the recent three years （P 〉 0. 05 ）. Conclusions The severity of antimicrobial resistance is soaring. Adhering to bacterial resistance monitoring has important meaning in directing the rational application of antibiotics and effectively controlling the bacterial infection.

关 键 词：病原菌 耐药性 变迁 

分 类 号：R446.5[医药卫生—诊断学]