甘草酸二胺肠溶胶囊预防抗结核药物性肝损的研究  

Study of glycyrrhizin diamine enteric-coated capsules in prevention of anti-tuberculosis drug-induced hepatotoxicity

作　　者：夏凡[1] 王琳[1] 汪学智[1] 

机构地区：[1]解放军第85医院肺科,上海200235

出　　处：《临床肺科杂志》2012年第2期286-288,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的比较研究甘草酸二胺肠溶胶囊对抗结核药物性肝损(ATDH)。方法将80例确诊初发肺结核患者随机分为实验组、对照组和空白组,分别施用甘草酸二胺肠溶胶囊、双环醇片和不用保肝药,观察180天标准抗结核治疗过程中的AT-DH发生情况及检测相关指标。结果实验组ATDH发生率25%,出现ATDH时间为101.20±23.70天;对照组ATDH发生率34.3%,出现ATDH时间为34.42±6.072天;空白组发生率44%,出现ATDH时间50.91±12.03天。实验组ATDH出现时间显著延后(P=0.007)。结论甘草酸二胺肠溶胶囊可延后ATDH的发生时间,降低其严重程度,并缓解抗结核期间炎性过敏反应。Objective To Compare the preventive effect of glycyrrhizin diamine enteric-coated capsules on ATDH. Methods 80 patients, who were confirmed tuberculosis, were randomly divided into the test group, control group and blank group. Glycyrrhizin diamine enteric-coated capsules, bicyclols and without drugs were respectively applied, the occurrence of ATDH were observed and related indica- tors were detected during 180 days in the standard anti-TB treatment. Results ATDH incidence in the test group was 25%, and it appeared at 101.20 ± 23.70 day;ATDH incidence in the control group was 34. 3% , and it appeared at 34. 42 ±6. 072 day. And the incidence in the blank group was 44% , and it appeared at 50. 91 ± 12. 03 day. The test group was significantly delayed（ P = 0. 007 ） , and ALT values were lower（ P = 0. 046）. Multiple comparisons in eosinophil ratio of the three groups, showed that the test group was significantly lower than the control group and blank group （ P = 0. 024 ）. Conclusions Glycyrrhizin diamine enteric-coated capsules may delay the occurrence of ATDH, reduce their severity, and alleviate allergic inflammation in tuberculosis.

关 键 词：抗结核治疗 药物性肝损 预防治疗 

分 类 号：R52[医药卫生—内科学]