通络中药结合自体外周血干细胞移植治疗糖尿病足的疗效及其对血清VEGF、bFGF的影响  

Therapeutic effect of Tongluo herbal drugs combined with PBSCT for treating diabetic foot and the effect on serum VEGF,bFGF level

作　　者：高怀林[1] 丁来标[1] 曹月香[1] 李会玉[1] 孔青[1] 王立业[1] 尹晓华[1] 

机构地区：[1]河北医科大学附属以岭医院/河北省中医药络病理论指导糖尿病足防治重点研究室,石家庄050091

出　　处：《疑难病杂志》2012年第1期26-28,共3页Chinese Journal of Difficult and Complicated Cases

基　　金：河北省中医药管理局科研汁划项目(No.20009166)

摘　　要：目的探讨通络中药结合自体外周血干细胞移植治疗糖尿病足的临床疗效及其对患者血清血管内皮生长因子(VEGF)、血清碱性成纤维细胞生长因子(bFGF)的影响。方法将60例糖尿病足患者随机分为通络+移植组(通心络结合自体外周血于细胞移植)和干细胞移植组(于细胞移植)各30例。于移植前、移植后12周,观察临床疗效及血清VEGF、bFGF水平的变化。结果通络+移植组和血细胞移植组患者的疼痛、冷感、麻木和间歇性跛行等症状治疗后较治疗前均明显缓解(P<0.01),除间歇性跛行外,通络+移植组临床症状评分优于干细胞移植组(p<0.05或P<0.01),2组患者移植后血清VEGF和bFGF与治疗前相比,差异无统计学意义(P>0.05)。结论通络中药结合自体外周血干细胞移植治疗糖尿病足,可提高临床疗效,不会导致血清VECF、bFGF水平增高。Objective To observe the clinical curative effect of treating diabetic foot（DF） with Tongluo herbal drugs combined with autologous peripheral blood cell transplantation（PBSCT） and its effect on serum vascular endothelial growth factor（VEGF） and serum alkaline fibroblast growth factor（bFGF） levels.Methods The sixty patients with diabetic foot were divided into Tongluo＋transplantation group（using peripheral blood stem cell transplantation combined with Tongluo herbal） and stem cell group（using peripheral blood stem cell transplantation） at random.The therapeutic effect was observed and the changes of bFGF and VEGF level was detected before treating and after 12 weeks.Results The symptoms such as pain,the feeling of cold,paralysis and intermission lameness of both Tongluo herbal＋transplantation group and stem cell group were obviously improved（P0.01）.besides the patients＇clinical symptom score in the two groups were significantly different（P0.05 or P0.01）,the Tongluo＋transplantation group was superior to stem cell group.There was no statistics significance compared the levels of serum bFGF and VEGF level in both two groups alter treatment with before treatment （P0.05）.Conclusion Tongluo herbal drugs combined with autologous PBSCT could improve the clinical curative effect in the diabetic foot（DF）,and it would not influence the increase of levels of VEGF and bFGF.

关 键 词：通络中药 干细胞移植 糖尿病足 血管内皮生长因子 碱性成纤维细胞生长因子 

分 类 号：R587.2[医药卫生—内分泌]