可降解聚合物溶胀性能对给药系统释药效果的影响  

Effect of Degradable Polymer Swelling Property on Release Performance of Controlled Drug Delivery System

作　　者：高扬[1] 王小鹏[1] 陈天宁[1] 

机构地区：[1]西安交通大学机械工程学院,西安710049

出　　处：《西安交通大学学报》2012年第1期114-119,共6页Journal of Xi'an Jiaotong University

基　　金：国家高技术研究发展计划资助项目(2006AA04Z330);国家自然科学基金资助项目(50705074);中央高校基本科研业务费专项资金资助项目

摘　　要：针对以乳酸-羟基乙酸共聚物(PLGA)作为药物载体的新型贮库式微孔结构缓控释给药系统,为量化PLGA溶胀特性对释药效果的影响,在模拟体液环境下,以具有不同单体质量比的PL-GA膜片上的微孔为研究对象,对PLGA在降解过程中的溶胀现象进行了实验研究,得到单体质量比为50∶50的PLGA的微孔径向溶胀速率约为2.7×10-10 m/s,质量比为65∶35的PLGA的微孔径向溶胀速率约为6.6×10-11 m/s.以单体质量比为50∶50的PLGA为例,将实验得到的微孔溶胀速率作为边界条件,对考虑PLGA溶胀作用前、后的微孔给药系统释药过程进行了有限元模拟,结果表明:聚合物溶胀使给药系统释药时间从无溶胀时的16d延长到33d;不考虑溶胀时,PL-GA基体仅起承载药物的作用,而考虑溶胀后,微孔和PLGA基体共同承担药物释放功能,其中近40%的药物通过微孔释放,近60%的药物通过聚合物载体释放;给药系统在整个释药过程中累积释药比率线性度较好.To quantitate the effect of poly（lactic-co-glycolic acid）（PLGA） swelling property on the drug release performance of the novel microholes controlled drug delivery system（MCDDS）,swelling experiments were conducted with different monomer ratios of PLGA,and the results show that the changing rates of microholes caused by the PLGA swelling reach 2.7×10-10 m/s of 50∶50 PLGA and 6.6×10-11 m/s of 65∶35 PLGA.Taking 50∶50 PLGA for example,the release processes of MCDDS were simulated by the finite element method with swelling rate as the boundary condition.Results show that the release period of MCDDS extends from 16 days without polymer swelling to 33 days as the PLGA swelling is considered;the matrix of PLGA only serves as a carrier without polymer swelling,whereas the polymer matrix and the microholes both play important roles in drug releasing when the swelling is considered,nearly 40% drug releases through microholes and 60% drug releases through polymer matrix.The cumulative released drug in the whole releasing process maintains approximate linearity.

关 键 词：药物释放系统 微孔 降解 溶胀 释药比率 

分 类 号：TB324[一般工业技术—材料科学与工程]