潍坊地区女性HPV的感染情况及基因亚型分析  

Female infection status and genetic subtypes analysis of human papillomavirus in Weifang area

作　　者：裴景亮[1] 齐立中 李建花[1] 李猛[1] 耿会娟[1] 

机构地区：[1]潍坊医学院附属医院山东省"十二五"高校临床检验诊断学重点实验室,山东潍坊261031 [2]山东省潍坊市中心医院,261041

出　　处：《检验医学与临床》2012年第1期7-9,共3页Laboratory Medicine and Clinic

摘　　要：目的研究潍坊市女性人群人乳头瘤病毒(HPV)的感染情况、年龄特征及基因型分布,为HPV感染的防治提供理论依据。方法采用核酸分子导流杂交分型技术对1 358例女性患者进行HPV分型检测,并对感染情况及基因亚型分布进行统计学分析。结果 (1)1 358例女性中HPV阳性424例,阳性率为31.22%,感染者中单一感染365例占86.08%,二重以上感染59例占13.92%。<30岁和大于或等于51岁女性是HPV感染高峰,与其他年龄段比较差异有统计学意义(P<0.05)。(2)424例阳性标本共检出HPV 519株,分为19个亚型。分离率高的前5个基因型是HPV16(16.28%)、HPV58(11.63%)、HPV6(10.08%)、HPV33(9.30%)、HPV52(8.53%)。结论 HPV感染具有一定的地域性,开展HPV基因型的检测对宫颈疾病的防治具有重要意义。Objective To study the female infection status,age characteristics and genotypes distribution of human papillomavirus（HPV） in Weifang area,and to provide a theoretic basis for therapy and prevention against HPV infection.Methods 1 358 female patients were detected for HPV DNA genotypes by DNA hybridization genotyping technique and performed the statistical analysis on the infection status and genetic subtypes distribution.Results（1） Among 1 358 female patients,424 cases were positive HPV with the positive rate of 31.22%.The rate of single infection with HPV was 86.08%（365/424） and the multiple infections rate was 13.92%（59/424）.Females 30 years old and ≥51 years old were HPV infection peaks,showing significant difference compared with other age groups（P0.05）.（2） 519 strains of HPV were isolated from 424 positive samples,including 19 subtypes.The highest isolation rates of genotypes were in turn HPV16（16.28%）,HPV58（11.63%）,HPV6（10.08%）,HPV33（9.30%） and HPV52（8.53%）.Conclusion HPV infections have certain regional character.Conducting the genotypes detection of HPV has important significance in the prevention and treatment of cervical diseases.

关 键 词：人乳头瘤病毒 基因亚型 多重感染 

分 类 号：R373.9[医药卫生—病原生物学]