母子俩接种卡介苗后发生皮肤寻常狼疮  

Lupus Valgaris at the Site of Bacillus Calmette-Guerin Vaccination:Report on the Mother and Her Son

作　　者：翁小满[1] 陈小华[1] 邢燕[1] 

机构地区：[1]首都医科大学附属北京友谊医院,北京热带医学研究所,北京100050

出　　处：《中国皮肤性病学杂志》2012年第1期57-58,共2页The Chinese Journal of Dermatovenereology

基　　金：北京市卫生局青年基金(QN2009-003);首都医科大学基础-临床合作基金-北京市李桓英基金会联合课题(09JL-L05)

摘　　要：母子俩分别在儿童期接种卡介苗(BCG)后,均在接种部位发生寻常狼疮。2例均在接种处出现丘疹、结节融合的、直径≥10.0cm的棕红色浸润性斑块,已持续达15～30年。玻片压诊呈现"苹果酱结节"。结核菌素试验(PPD)阳性。皮损组织病理学检查示:真皮可见上皮样细胞、多核巨细胞,大量淋巴细胞形成的"上皮样细胞肉芽肿",无干酪样坏死。抗酸染色与PCR扩增分枝杆菌均为阴性。诊断:寻常狼疮(BCG接种部位)。A mother and her son happened respectively Lupus vulgaris （LV） at the site of Bacillus Calmette-Gu6rin （BCG） vaccination in their childhood. The manifestation of lesions were similar and presented with a brown reddish infiltrated plague mixed numerous papules and nodules over 10.0cm in diameter. Diascopic exami- nation showed the presence of ＂apple jelly＂ colored nodules, The lesions had continued for 15 -30 years respectively in both two cases and PPD were strongly positive. Histopathological examination showed diffuse in filtration of mixed epithelioid cells, lymphocyte cells and sLanghuans-type giant cell, formed ＂epithelioid cell granuloma＂ without caseation necrosis in the dermal. No Mycobacteria were found by Acid-Fast sttaining and PCR. Diagnosis of lupus vulzaris at the site of BCG vaccination was made.

关 键 词：卡介苗 寻常狼疮 并发症 

分 类 号：R754.9[医药卫生—皮肤病学与性病学]