β-磷酸三钙/α-半水硫酸钙复合人工骨体外降解速度可与成骨一致  

In vitro degradation mechanism of beta-tricalcium phosphate/alpha-calcium sulfate hemihydrates bone graft

作　　者：李鹏[1] 毛克亚[1] 江涛[2] 杨云[2] 崔福斋[3] 侯喜军[1] 梁茂华[1] 杜明奎[1] 王继芳[1] 王岩[1] 

机构地区：[1]解放军总医院骨科,北京市100853 [2]中国科学院理化技术研究所,北京市100853 [3]清华大学材料工程系,北京市100853

出　　处：《中国组织工程研究与临床康复》2011年第51期9501-9504,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：国家自然科学基金(50830102);课题名称:仿生骨再生植入材料的相关科学问题研究;国家国家863计划(2009AA02Z405);课题名称:微创手术治疗骨质疏松椎体压缩骨折相关研究~~

摘　　要：背景:骨修复材料的理想降解速度应该与新骨形成速度相匹配,逐渐被新生骨逐渐爬行替代。目的:探讨β-磷酸三钙/α-半水硫酸钙复合人工骨的体外降解速度。方法:将β-磷酸三钙/α-半水硫酸钙复合人工骨、β-磷酸三钙、α-半水硫酸钙试件置于PBS模拟体液中,测量不同浸泡时间的pH变化、试件降解率和压缩强度变化。结果与结论:在模拟体液中复合人工骨和α-半水硫酸钙的pH值随时间延长逐渐降低,而β-磷酸三钙的pH值变化不大,4周后复合人工骨的pH值稳定在5.6左右。PBS模拟体液浸泡过程中,复合人工骨与α-半水硫酸钙的质量和压缩强度均随时间延长而不断降低,而β-磷酸三钙的质量随时间的变化降低较小。说明β-磷酸三钙/α-半水硫酸钙复合人工骨通过物理溶解而逐渐降解,其体外降解率介于β-磷酸三钙和α-半水硫酸钙之间。BACKGROUND： The ideal degradation rate of bone repair materials should be matched with the speed of new bone formation, and the bone repair materials are replaced by new bone gradually via creeping substitution. OBJECTIVE： To investigate the in vitro degradation mechanism and degradation speed of β-tricalcium phosphate/α-calcium sulphate hemihydrates （β-TCP/α-CSH） bone graft. METHODS： β-TCP/α-CSH, β-TCP and α-CSH samples were soaked in PBS liquid. The pH value, degradation rate and compressive stress were examined. RESULTS AND CONCLUSION： In the PBS liquid, the pH value of β-TCP/α-CSH bone graft and α-CSH gradually decreased with the soaked time, but that of β-TCP changed little. After 4 weeks, the pH value of β-TCP/α-CSH bone graft and α-CSH was stabilized to about 5.6. The weight and compressive stress of β-TCP/α-CSH bone graft and α-CSH were gradually decreased with the soaked time in the PBS liquid, but those of β-TCP decreased little. β-TCP/α-CSH bone graft can gradually degrade through physical dissolution in vitro, and the degradation rate is lower than that of β-TCP but higher than that of α-CSH.

关 键 词：Β-磷酸三钙 α-半水硫酸钙 人工骨 复合植骨材料 降解 

分 类 号：R318[医药卫生—生物医学工程]