记忆合金材料弹力金属支架在犬肺组织瓣重建气管缺损中的应用  

Application of a memory alloy elastic metal stent in reconstruction of tracheal defects by pulmonary tissue flaps in dogs

作　　者：纪子钊[1] 陈刚[2] 张苏宁[1] 石文君[1] 

机构地区：[1]中国医科大学盛京医院胸外科,辽宁省沈阳市110004 [2]九江市第一人民医院心胸外科,江西省九江市332000

出　　处：《中国组织工程研究与临床康复》2011年第51期9549-9552,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：卫生部立项资助项目(WKZ-2000-1-17)~~

摘　　要：背景：生物相容性好的内衬支架是肺组织瓣成功修补气管缺损的关键,记忆合金支架成为目前研究热点。目的：探讨应用自体肺组织瓣内衬金属弹力支架替代气管缺损的可行性。方法：由中国医科大学附属盛京医院动物实验室提供杂种成年犬14只,雄性8只,雌性6只,体质量12~26kg,气管整段切除3cm或5cm,采用自体肺组织瓣内衬金属弹力支架替代气管缺损方法行胸段气管重建。结果与结论：4只犬死亡,死于并发症及其他原因,10只成活,吻合口愈合良好,食管钡透通畅。结果表明自体肺组织瓣内衬金属弹力支架替代气管缺损是一种可行的气管重建方法。BACKGROUND： Lined stent containing good biocompatibility is the key of successful repair of tracheal defect by pulmonary tissue flap. Memory alloy stent is the research hotspot now. OBJECTIVE： To explore the possibility of autologous pulmonary tissue flap lined with elastic metal stent in replacing tracheal defect. METHODS： Fourteen hybrid adult dogs came from animal laboratory of Shengjing Hospital of China Medical University were involved. Eight dogs were male and six ones were female with weight of 12-26 kg. The entire trachea of 3 cm or 5 cm was removed in all dogs. Thoracic tracheal reconstruction was performed with autologous pulmonary tissue flap lined with elastic metal stent to replace the tracheal defect. RESULTS AND CONCLUSION： Four dogs died of the complications and other reasons. Ten dogs survived, and their stomas were good and the barium flux was unobstructed. The replacement of tracheal defect by autologous pulmonary tissue flap lined with elastic metal stent is a possible tracheal reconstruction method.

关 键 词：气管缺损 肺 组织瓣 气管重建 记忆合金支架 

分 类 号：R318[医药卫生—生物医学工程]