骨修复材料在骨折及骨缺损治疗中的价值  

Value of bone repair materials in the treatment of fractures and bone defects

作　　者：翟希[1] 

机构地区：[1]沈阳医学院附属奉天医院手外2科,辽宁省沈阳市110024

出　　处：《中国组织工程研究与临床康复》2011年第51期9655-9658,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：背景:人工骨材料作为骨移植替代物修复骨缺损,是医学和生物材料学领域内的一项重要研究课题。目的:总结近年有关骨修复材料在骨折及骨缺损中的应用现状。方法:由作者应用计算机检索维普数据库中与骨修复材料治疗骨折、骨缺损有关的文献,检索时限为1998-01/2009-10。检索关键词为"骨折,骨修复,假体置换,材料"。纳入标准:①选取针对性强,相关度高的文献。②排除一些重复性研究。对资料进行初审,并查看每篇文献后的引文。最终纳入26篇文献进入结果分析。结果与结论:目前研究较多的骨修复材料有纳米羟基磷灰石/聚酰胺66,脱钙骨基质,硫酸钙颗粒,纳米晶羟基磷灰石/胶原复合材料等。纳米级组织工程骨材料则是利用纳米技术在纳米结构单元或纳米数量级(1～100nm)下生产的新型材料,研制成的纳米羟基磷灰石/胶原骨经动物实验研究证实,比普通羟基磷灰石有更为优越的生物相容性和生物活性,无细胞毒性,能促进和加快骨创的愈合。BACKGROUND：Using artificial bone materials as bone graft substitutes to repair bone defects is one of the important research subjects in medical and biomaterial fields.OBJECTIVE：To summarize the recent application status of bone repair materials in the treatment of fracture and bone defect.METHODS：An online search of VIP database was performed for articles related to the application of bone repair materials in the treatment of fractures and bone defects published between January 1998 and October 2009,with the keyords of ＂fracture＂,＂bone repair＂,＂prosthetic replacement＂ and ＂material＂.Articles with a high level of correlation were included.Repetitive studies were excluded.The collected articles were analyzed.The references of each article were checked.A total of 26 articles were retained in the end.RESULTS AND CONCLUSION：The recent researches on bone repair materials are focused on nano-hydroxyapatite/polyamides-66,demineralized bone matrix,calcium sulfate particles and nanometer crystal hydroxyapatite/collagen composite.Nano tissue-engineered bone material is a new kind of material using nanotechnology.It is based on nano structured units or with the magnitude of 1 to 100 nm.Experiments on animals confirm that the developed nano-hydroxyapatite/collagen have better biocompatibility and bioactivity than regular hydroxyapatite.It promotes and accelerates bone wound healing.

关 键 词：骨折 骨缺损 假体置换 并发症 医学植入体 

分 类 号：R318[医药卫生—生物医学工程]